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oapen-20.500.12657-243822024-03-22T19:23:23Z Aging and Health Yashin, Anatoliy I. Jazwinski, S. Michal Medicine & Public Health Gerontology Geriatrics Genetics Bioinformatics Genomics Physiology Medicine thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKN Geriatric medicine Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. 2019-12-02 14:28:34 2020-04-01T09:57:25Z 2020-04-01T09:57:25Z 2014 book 1005732 OCN: 1135846389 9783318027303 http://library.oapen.org/handle/20.500.12657/24382 eng application/pdf n/a 1005732.pdf Karger 10.1159/issn.0074-1132 103014 10.1159/issn.0074-1132 7bca2022-473f-4da6-bdd7-3daa111614de b818ba9d-2dd9-4fd7-a364-7f305aef7ee9 9783318027303 Knowledge Unlatched (KU) 103014 KU Select 2018: STEM Backlist Books Knowledge Unlatched open access
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Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging.
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