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oapen-20.500.12657-323422021-11-12T16:31:23Z Chapter 13 Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies Jordan, Bénédicte F. Sonveaux, Pierre tumor systematic therapies hypoxia radiotherapy cancer sensitivity tumor systematic therapies hypoxia radiotherapy cancer sensitivity Blood Hemodynamics Magnetic resonance imaging Neoplasm Oxygen Perfusion Radiation therapy Vasodilation bic Book Industry Communication::P Mathematics & science::PD Science: general issues Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953). Because of this so-called “oxygen enhancement effect”, the radiation dose required to achieve the same biologic effect is about three times higher in the absence of oxygen than in the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009). Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of fractionated radiotherapy (Rojas et al., 1992). 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2016-08-01 23:55 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2016-12-31 23:55:55 2019-10-04 14:29:40 2020-04-01T14:06:57Z 2020-04-01T14:06:57Z 2011 chapter 612595 OCN: 1030814339 http://library.oapen.org/handle/20.500.12657/32342 eng application/pdf n/a 612595.pdf InTechOpen Advances in Cancer Therapy 10.5772/23332 10.5772/23332 09f6769d-48ed-467d-b150-4cf2680656a1 f8819a36-74fb-4e74-ad33-23e97c839e51 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) 1 243188 FP7 FP7 Ideas: European Research Council FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013) open access
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Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species
(ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes
the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and
human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells
become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953).
Because of this so-called “oxygen enhancement effect”, the radiation dose required to
achieve the same biologic effect is about three times higher in the absence of oxygen than in
the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009).
Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well
oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of
fractionated radiotherapy (Rojas et al., 1992).
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