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oapen-20.500.12657-323462021-11-12T16:25:55Z Chapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery Schäfer, Thomas Özalp, Veli C. Özalp, Veli C. Schäfer, Thomas drug delivery nanoparticles drug delivery nanoparticles Aptamer Protein bic Book Industry Communication::P Mathematics & science::PD Science: general issues Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found applicability in the development of novel drug delivery systems by easily overcoming toxicity problem. However, specificity of delivery has remained as a challenge. Developments in the methods of reaching to targeted tissue have lead to new and improved drug delivery platforms. Recently, active targeting has been incorporated by cell specific ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained popularity in construction of novel actively targeted drug delivery systems (Ozalp et al., 2011). Considerable proportions of aptamer-based delivery systems have been incorporated to a variety of nanomaterials in order to improve their specific targeting properties (Chen et al., 2011; Zhou et al., 2011). 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2016-08-01 23:55 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2016-12-31 23:55:55 2019-10-04 14:28:10 2020-04-01T14:07:00Z 2020-04-01T14:07:00Z 2012 chapter 612587 OCN: 1030822012 http://library.oapen.org/handle/20.500.12657/32346 eng application/pdf n/a 612587.pdf InTechOpen The Delivery of Nanoparticles 10.5772/35188 10.5772/35188 09f6769d-48ed-467d-b150-4cf2680656a1 3b2ebb32-419e-468f-b007-0649f0e5b9d9 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) 1 209842 FP7 FP7 Ideas: European Research Council FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013) open access
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Drug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with
traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found
applicability in the development of novel drug delivery systems by easily overcoming
toxicity problem. However, specificity of delivery has remained as a challenge.
Developments in the methods of reaching to targeted tissue have lead to new and improved
drug delivery platforms. Recently, active targeting has been incorporated by cell specific
ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained
popularity in construction of novel actively targeted drug delivery systems (Ozalp et al.,
2011). Considerable proportions of aptamer-based delivery systems have been incorporated
to a variety of nanomaterials in order to improve their specific targeting properties (Chen et
al., 2011; Zhou et al., 2011).
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