612584.pdf
Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and...
| Γλώσσα: | English |
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| Έκδοση: |
InTechOpen
2019
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| Περίληψη: | Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by
germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most
prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal
cancers (Lynch & de la Chapelle, 2003). |
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