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oapen-20.500.12657-478572021-04-16T00:41:42Z Chapter 5 Respiratory Syncytial Virus Jha, Akhilesh Jarvis, Hannah Fraser, Clementine Openshaw, Peter viral lung disease, RSV, paediatric infections, bronchiolitis, mucosal immunity bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million cases in children younger than 5 years, with 10% requiring hospital admission and up to 199,000 dying of the disease. There is growing evidence that severe infantile RSV bronchiolitis, a condition characterised by an inflammatory reaction to the virus, is associated with later childhood wheeze in some vulnerable children; however, a direct causal relationship with asthma has not yet been established. It is also increasingly recognised as a cause of morbidity and mortality in those with underlying airway disease, immunocompromise and frail elderly persons. Novel molecular based diagnostic tools are becoming established but treatment largely remains supportive, with palivizumab being the only licensed agent currently available for passive prophylaxis of selected pre-term infants. Whilst effective treatments remain elusive, there is optimism about the testing of novel antiviral drugs and the development of vaccines that may induce long-lasting immunity without the risk of disease augmentation. 2021-04-15T11:37:39Z 2021-04-15T11:37:39Z 2016 chapter https://library.oapen.org/handle/20.500.12657/47857 eng application/pdf Attribution-NonCommercial 4.0 International Bookshelf_NBK442240.pdf European Respiratory Society SARS, MERS and other Viral Lung Infections 083e663a-b576-4fdd-8566-4b996eba01f8 5cf1fb3c-d029-40f8-9de5-4f395f9e3256 d859fbd3-d884-4090-a0ec-baf821c9abfd Wellcome 38 Sheffield Wellcome Trust Wellcome open access
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Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million cases in children younger than 5 years, with 10% requiring hospital admission and up to 199,000 dying of the disease. There is growing evidence that severe infantile RSV bronchiolitis, a condition characterised by an inflammatory reaction to the virus, is associated with later childhood wheeze in some vulnerable children; however, a direct causal relationship with asthma has not yet been established. It is also increasingly recognised as a cause of morbidity and mortality in those with underlying airway disease, immunocompromise and frail elderly persons. Novel molecular based diagnostic tools are becoming established but treatment largely remains supportive, with palivizumab being the only licensed agent currently available for passive prophylaxis of selected pre-term infants. Whilst effective treatments remain elusive, there is optimism about the testing of novel antiviral drugs and the development of vaccines that may induce long-lasting immunity without the risk of disease augmentation.
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