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oapen-20.500.12657-491542021-11-23T13:55:07Z Chapter Nature-Inspired Nanotechnology and Smart Magnetic Activation: Two Groundbreaking Approaches Toward a New Generation of Biomaterials for Hard Tissue Regeneration Sprio, Simone Sandri, Monica Iafisco, Michele Panseri, Silvia Montesi, Monica Ruffini, Andrea Adamiano, Alessio Ballardini, Alberto Tampieri, Anna diatomite, porous material, nanovector, bioconjugation, drug delivery bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PST Botany & plant sciences::PSTV Phycology, algae & lichens Diatomite is a natural porous silica material of sedimentary origin, formed by remains of diatom skeletons called “frustules.” The abundance in many areas of the world and the peculiar physico-chemical properties made diatomite an intriguing material for several applications ranging from food production to pharmaceutics. However, diatomite is a material still rarely used in biomedical applications. In this chapter, the properties of diatom frustules reduced to nanoparticles, with an average diameter less than 350 nm, as potential drug vectors are described. Their biocompatibility, cellular uptake, and capability to transport molecules inside cancer cells are discussed. Preliminary studies of in vivo toxicity are also presented. 2021-06-02T10:07:58Z 2021-06-02T10:07:58Z 2016 chapter ONIX_20210602_10.5772/63229_268 https://library.oapen.org/handle/20.500.12657/49154 eng application/pdf n/a 50571.pdf InTechOpen 10.5772/63229 10.5772/63229 09f6769d-48ed-467d-b150-4cf2680656a1 FP7-NMP-2012-SMALL-6 310637 open access
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Diatomite is a natural porous silica material of sedimentary origin, formed by remains of diatom skeletons called “frustules.” The abundance in many areas of the world and the peculiar physico-chemical properties made diatomite an intriguing material for several applications ranging from food production to pharmaceutics. However, diatomite is a material still rarely used in biomedical applications. In this chapter, the properties of diatom frustules reduced to nanoparticles, with an average diameter less than 350 nm, as potential drug vectors are described. Their biocompatibility, cellular uptake, and capability to transport molecules inside cancer cells are discussed. Preliminary studies of in vivo toxicity are also presented.
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