| spelling |
oapen-20.500.12657-492222021-11-23T13:58:48Z Chapter Assessing the Performance of Personal Protective Equipment1 Kechagiadakis, Georgios Pirlot, Marc Schistosoma mansoni, drug screening, histone‐modifying enzymes, protein kinases, inhibitors, RNA interference bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology Schistosomiasis is the second most prevalent parasitic disease in the world. Currently, the treatment of this disease relies on a single drug, praziquantel, and due to the identification of resistant parasites, the development of new drugs is urged. The demand for the development of robust high‐throughput parasite screening techniques is increasing as drug discovery research in schistosomiasis gains significance. Here, we review the most common methods used for compound screening in the parasites life stages and also summarize some of the methods that have been recently developed. In addition, we reviewed the methods most commonly implemented to search for promising targets and how they have been used to validate new targets against the parasite Schistosoma mansoni. We also review some promising targets in this parasite and show the main approaches and the major advances that have been achieved by those studies. Moreover, we share our experiences in schistosomiasis drug discovery attained with our S. mansoni drug screening platform establishment. 2021-06-02T10:09:49Z 2021-06-02T10:09:49Z 2017 chapter ONIX_20210602_10.5772/65778_336 https://library.oapen.org/handle/20.500.12657/49222 eng application/pdf n/a 54088.pdf InTechOpen 10.5772/65778 10.5772/65778 09f6769d-48ed-467d-b150-4cf2680656a1 FP7-SEC-2011-1 284747 open access
|
| description |
Schistosomiasis is the second most prevalent parasitic disease in the world. Currently, the treatment of this disease relies on a single drug, praziquantel, and due to the identification of resistant parasites, the development of new drugs is urged. The demand for the development of robust high‐throughput parasite screening techniques is increasing as drug discovery research in schistosomiasis gains significance. Here, we review the most common methods used for compound screening in the parasites life stages and also summarize some of the methods that have been recently developed. In addition, we reviewed the methods most commonly implemented to search for promising targets and how they have been used to validate new targets against the parasite Schistosoma mansoni. We also review some promising targets in this parasite and show the main approaches and the major advances that have been achieved by those studies. Moreover, we share our experiences in schistosomiasis drug discovery attained with our S. mansoni drug screening platform establishment.
|
