56417.pdf

The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in v...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Γλώσσα:English
Έκδοση: InTechOpen 2021
id oapen-20.500.12657-49253
record_format dspace
spelling oapen-20.500.12657-492532021-11-23T14:02:15Z Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling Ramal Sanchez, Marina Mattioli, Mauro Valbonetti, Luca Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia germline stem cells, spermatozoa, membrane, signalling, fertility bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth & development::MFKC Reproductive medicine The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors. 2021-06-02T10:10:38Z 2021-06-02T10:10:38Z 2018 chapter ONIX_20210602_10.5772/intechopen.69964_367 https://library.oapen.org/handle/20.500.12657/49253 eng application/pdf n/a 56417.pdf InTechOpen 10.5772/intechopen.69964 10.5772/intechopen.69964 09f6769d-48ed-467d-b150-4cf2680656a1 H2020-MSCA-ITN-2015 675526 open access
institution OAPEN
collection DSpace
language English
description The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors.
title 56417.pdf
spellingShingle 56417.pdf
title_short 56417.pdf
title_full 56417.pdf
title_fullStr 56417.pdf
title_full_unstemmed 56417.pdf
title_sort 56417.pdf
publisher InTechOpen
publishDate 2021
_version_ 1771297413546377216