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oapen-20.500.12657-493162021-06-02T14:22:59Z Chapter Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens Nombela, Ivan Chico, Veronica Puente-Marin, Sara Ortega-Villaizan, M. nucleated red blood cells, erythrocytes, immune response, cytokines, antimicrobial peptides, virus, antigen presentation bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMF Pathology::MMFM Medical microbiology & virology It has recently come to light that nucleated red blood cells (RBCs) of fish, amphibians, reptiles and birds are multifunctional cells, because in addition to being involved in gas exchange and transport, it has also been reported that they respond to pathogens by means of (i) phagocytosis, (ii) antigen presentation, (iii) production of cytokines and antimicrobial peptides, (iv) regulation of complement system, and (v) exerting paracrine molecular communication with other immune cells and modulating their functions. Similarly, human cord blood nucleated RBCs have been shown to exert a regulatory function in the innate immune response, by means of the suppression of the production of inflammatory cytokines. This chapter comprises the study of the implications of nucleated RBCs as mediators of both branches of immune system (innate and adaptive immune responses). 2021-06-02T10:12:02Z 2021-06-02T10:12:02Z 2019 chapter ONIX_20210602_10.5772/intechopen.80545_430 https://library.oapen.org/handle/20.500.12657/49316 eng application/pdf n/a 63797.pdf InTechOpen 10.5772/intechopen.80545 10.5772/intechopen.80545 09f6769d-48ed-467d-b150-4cf2680656a1 178e65b9-dd53-4922-b85c-0aaa74fce079 European Research Council (ERC) 639249 H2020 European Research Council H2020 Excellent Science - European Research Council open access
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It has recently come to light that nucleated red blood cells (RBCs) of fish, amphibians, reptiles and birds are multifunctional cells, because in addition to being involved in gas exchange and transport, it has also been reported that they respond to pathogens by means of (i) phagocytosis, (ii) antigen presentation, (iii) production of cytokines and antimicrobial peptides, (iv) regulation of complement system, and (v) exerting paracrine molecular communication with other immune cells and modulating their functions. Similarly, human cord blood nucleated RBCs have been shown to exert a regulatory function in the innate immune response, by means of the suppression of the production of inflammatory cytokines. This chapter comprises the study of the implications of nucleated RBCs as mediators of both branches of immune system (innate and adaptive immune responses).
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