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oapen-20.500.12657-533172022-03-16T02:55:18Z Antisense RNA Design, Delivery, and Analysis Arechavala-Gomeza, Virginia Garanto, Alejandro RNA therapeutics Antisense technology Therapeutic design Oligonucleotides Model systems Oligonucleotide-mediated toxicology Open Access bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMJ Clinical psychology::MMJT Psychotherapy bic Book Industry Communication::P Mathematics & science::PN Chemistry bic Book Industry Communication::T Technology, engineering, agriculture::TG Mechanical engineering & materials::TGM Materials science This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries. 2022-03-15T07:52:49Z 2022-03-15T07:52:49Z 2022 book ONIX_20220314_9781071620106_33 9781071620106 https://library.oapen.org/handle/20.500.12657/53317 eng Methods in Molecular Biology application/pdf n/a 978-1-0716-2010-6.pdf https://link.springer.com/978-1-0716-2010-6 Springer Nature Humana 10.1007/978-1-0716-2010-6 10.1007/978-1-0716-2010-6 6c6992af-b843-4f46-859c-f6e9998e40d5 f1d9faa0-0bd1-4fe9-9e3a-99696242d3f6 9781071620106 Humana 2434 422 New York [grantnumber unknown] European Cooperation in Science and Technology COST open access
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This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries.
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