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oapen-20.500.12657-54829
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oapen-20.500.12657-548292022-06-01T02:58:04Z Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems COPPI, Elisabetta Chimica Chimica inorganica Fisiologia Metabolismo Acidi nucleici Open Access bic Book Industry Communication::M Medicine Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells. 2022-05-31T10:14:26Z 2022-05-31T10:14:26Z 2008 book ONIX_20220531_9788884539052_113 2612-8020 9788884539052 9788884539045 9788892737891 https://library.oapen.org/handle/20.500.12657/54829 eng Premio Tesi di Dottorato application/pdf n/a 9788884539052.pdf https://books.fupress.com/isbn/9788884539052 Firenze University Press 10.36253/978-88-8453-905-2 10.36253/978-88-8453-905-2 bf65d21a-78e5-4ba2-983a-dbfa90962870 9788884539052 9788884539045 9788892737891 1 192 Firenze open access
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OAPEN
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DSpace
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| language |
English
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| description |
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells.
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| title |
9788884539052.pdf
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| spellingShingle |
9788884539052.pdf
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| title_short |
9788884539052.pdf
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| title_full |
9788884539052.pdf
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| title_fullStr |
9788884539052.pdf
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| title_full_unstemmed |
9788884539052.pdf
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| title_sort |
9788884539052.pdf
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| publisher |
Firenze University Press
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| publishDate |
2022
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| url |
https://books.fupress.com/isbn/9788884539052
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| _version_ |
1771297487587377152
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