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oapen-20.500.12657-54963
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oapen-20.500.12657-549632022-06-01T03:04:51Z Molecular imaging in Parkinson's disease Polito, Cristina bic Book Industry Communication::M Medicine The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus. 2022-05-31T10:18:02Z 2022-05-31T10:18:02Z 2011 book ONIX_20220531_9788866550419_247 2612-8020 9788866550419 9788866550372 9788892736450 https://library.oapen.org/handle/20.500.12657/54963 eng Premio Tesi di Dottorato application/pdf n/a 9788866550419.pdf https://books.fupress.com/isbn/9788866550419 Firenze University Press 10.36253/978-88-6655-041-9 10.36253/978-88-6655-041-9 bf65d21a-78e5-4ba2-983a-dbfa90962870 9788866550419 9788866550372 9788892736450 18 68 Firenze open access
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OAPEN
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DSpace
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| language |
English
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| description |
The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Flor-ence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
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| title |
9788866550419.pdf
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| spellingShingle |
9788866550419.pdf
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| title_short |
9788866550419.pdf
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| title_full |
9788866550419.pdf
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| title_fullStr |
9788866550419.pdf
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| title_full_unstemmed |
9788866550419.pdf
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| title_sort |
9788866550419.pdf
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| publisher |
Firenze University Press
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| publishDate |
2022
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| url |
https://books.fupress.com/isbn/9788866550419
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| _version_ |
1771297383679787008
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