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oapen-20.500.12657-550302022-06-01T03:08:20Z Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine Bernacchioni, Caterina bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSD Molecular biology This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved. 2022-05-31T10:19:41Z 2022-05-31T10:19:41Z 2012 book ONIX_20220531_9788866552192_314 2612-8020 9788866552192 9788866552185 9788892735644 https://library.oapen.org/handle/20.500.12657/55030 ita Premio Tesi di Dottorato application/pdf n/a 9788866552192.pdf https://books.fupress.com/isbn/9788866552192 Firenze University Press 10.36253/978-88-6655-219-2 This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved. 10.36253/978-88-6655-219-2 bf65d21a-78e5-4ba2-983a-dbfa90962870 9788866552192 9788866552185 9788892735644 26 152 Firenze open access
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This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.
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