Bookshelf_NBK572449.pdf
Chromosome segregation is conserved throughout eukaryotes. In most systems, it is solely driven by a spindle machinery that is assembled from microtubules. We have recently discovered that actin filaments that are embedded inside meiotic spindles (spindle actin) are needed for accurate chromosome se...
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Humana Press
2022
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oapen-20.500.12657-566932022-06-10T02:54:07Z Chapter 17 Visualization and Functional Analysis of Spindle Actin and Chromosome Segregation in Mammalian Oocytes Mogessie, Binyam Actin, Microtubules, Chromosomes, Meiosis, Oocytes, Eggs, Spindle, Fertility, High-resolution live microscopy bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences Chromosome segregation is conserved throughout eukaryotes. In most systems, it is solely driven by a spindle machinery that is assembled from microtubules. We have recently discovered that actin filaments that are embedded inside meiotic spindles (spindle actin) are needed for accurate chromosome segregation in mammalian oocytes. To understand the function of spindle actin in oocyte meiosis, we have developed high-resolution and super-resolution live and immunofluorescence microscopy assays that are described in this chapter 2022-06-09T10:16:44Z 2022-06-09T10:16:44Z 2019 chapter 9781071602188 9781071602218 https://library.oapen.org/handle/20.500.12657/56693 eng application/pdf Attribution 4.0 International Bookshelf_NBK572449.pdf Humana Press Cytoskeleton Dynamics 10.1007/978-1-0716-0219-5_22 10.1007/978-1-0716-0219-5_22 8cf70738-d164-4fbe-bf04-ca83ba19c992 f109903e-5ba3-4f5c-8b31-3f405e6b765b d859fbd3-d884-4090-a0ec-baf821c9abfd 9781071602188 9781071602218 Wellcome 29 Wellcome Trust Wellcome open access |
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English |
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Chromosome segregation is conserved throughout eukaryotes. In most systems, it is solely driven by a spindle machinery that is assembled from microtubules. We have recently discovered that actin filaments that are embedded inside meiotic spindles (spindle actin) are needed for accurate chromosome segregation in mammalian oocytes. To understand the function of spindle actin in oocyte meiosis, we have developed high-resolution and super-resolution live and immunofluorescence microscopy assays that are described in this chapter |
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Humana Press |
| publishDate |
2022 |
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1771297531466088448 |
