Bookshelf_NBK572925.pdf
Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin – deoxygenated-haemoglobin) combined wi...
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oapen-20.500.12657-566972022-06-10T02:54:08Z Chapter Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury Bale, Gemma Taylor, Nathan Mitra, Subhabrata Sudakou, Aleh Roever, Isabel de Meek, Judith Robertson, Nicola Tachtsidis, Ilias Near-infrared spectroscopy; Cerebral blood flow; Neonatal brain injury; Hypoxic-ischaemic encephalopathy; Clinical bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJW Paediatric medicine::MJWN Neonatal medicine Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin – deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick’s principle and uses HbD as a tracer; when a sudden change in SaO2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1 with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth. 2022-06-09T12:26:03Z 2022-06-09T12:26:03Z 2020 chapter 9783030344597 https://library.oapen.org/handle/20.500.12657/56697 eng application/pdf Attribution 4.0 International Bookshelf_NBK572925.pdf Springer Nature Oxygen Transport to Tissue XLI 10.1007/978-3-030-34461-0_1 10.1007/978-3-030-34461-0_1 6c6992af-b843-4f46-859c-f6e9998e40d5 ccf57905-ab3b-49f9-b482-fdf984cb3c17 d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030344597 Wellcome 7 Wellcome Trust Wellcome open access |
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English |
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Neonates with hypoxic-ischaemic (HI) brain injury were monitored
using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive
care unit. The aim of this work is to use the NIRS cerebral oxygenation data
(HbD = oxygenated-haemoglobin
– deoxygenated-haemoglobin) combined with
arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow
(CBF) based on the oxygen swing method, during spontaneous desaturation episodes.
The method is based on Fick’s principle and uses HbD as a tracer; when a
sudden change in SaO2 occurs, the change in HbD represents a change in tracer
concentration, and thus it is possible to estimate CBF. CBF was successfully calculated
with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation
events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g−1 min−1
with a range of 4 ml 100 g−1 min−1 to 60 ml 100 g−1 min−1. For infants with severe
HIE (as determined by magnetic resonance spectroscopy) CBF was significantly
lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth. |
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Springer Nature |
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2022 |
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