Bookshelf_NBK572926.pdf
Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental...
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Springer Nature
2022
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oapen-20.500.12657-566982022-06-10T02:54:08Z Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism Russell-Buckland, Joshua Tachtsidis, Ilias Broadband NIRS, Hypothermia, Systems biology bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings. 2022-06-09T12:33:31Z 2022-06-09T12:33:31Z 2020 chapter 9783030344597 https://library.oapen.org/handle/20.500.12657/56698 eng application/pdf Attribution 4.0 International Bookshelf_NBK572926.pdf Springer Nature Oxygen Transport to Tissue XLI 10.1007/978-3-030-34461-0_38 10.1007/978-3-030-34461-0_38 6c6992af-b843-4f46-859c-f6e9998e40d5 ccf57905-ab3b-49f9-b482-fdf984cb3c17 d859fbd3-d884-4090-a0ec-baf821c9abfd 9783030344597 Wellcome 8 104580/Z/14/Z Wellcome Trust Wellcome open access |
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English |
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Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings. |
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2022 |
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