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oapen-20.500.12657-623542024-03-27T14:14:50Z Chapter 1 A “C Odyssey” Levine, Mark Violet, Pierre-Christian Ebenuwa, Ifechukwude C. HongBin, Tu Wang, Yaohui acute sepsis; antioxidants; ascorbic acid; cancer treatment; infectious disease; infectious disease treatment; intravenous ascorbate; stem cell transplantation; vitamin c thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The nutritional biochemist Alfred E. Harper was a member of the Food and Nutrition Board of the National Research Council/National Academy of Sciences for many years, and chair of the Food and Nutrition Board from 1978 to 1982. The scientific bases for many Recommended Dietary Allowances (RDA) were prevention of deficiency with a margin of safety, often determined from depletion-repletion studies or balance experiments. As nutritional science has grown, and policy needs have changed, limitations of RDAs were recognized. Fundamental biochemical kinetics concepts can be the foundation for nutrient recommendations. Bioavailability experiments showed plasma and tissue concentrations were tightly controlled with oral administration of ascorbic acid. Reabsorption would be predicted in proximal renal tubules, concurrent with sodium-dependent vitamin C transporter1 localization. Accelerated ascorbic acid utilization in disease states may be a new frontier that can lead to discoveries for roles of ascorbic acid in disease treatment. 2023-04-12T13:51:15Z 2023-04-12T13:51:15Z 2020 chapter 9781138337992 https://library.oapen.org/handle/20.500.12657/62354 eng application/pdf Attribution-NonCommercial 4.0 International 9780429442025_10.1201_9780429442025-1.pdf Taylor & Francis Vitamin C CRC Press 10.1201/9780429442025-1 10.1201/9780429442025-1 7b3c7b10-5b1e-40b3-860e-c6dd5197f0bb b5f7db67-fe9c-4e84-b587-54aa1b8117c0 9781138337992 CRC Press 22 open access
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The nutritional biochemist Alfred E. Harper was a member of the Food and Nutrition Board of the National Research Council/National Academy of Sciences for many years, and chair of the Food and Nutrition Board from 1978 to 1982. The scientific bases for many Recommended Dietary Allowances (RDA) were prevention of deficiency with a margin of safety, often determined from depletion-repletion studies or balance experiments. As nutritional science has grown, and policy needs have changed, limitations of RDAs were recognized. Fundamental biochemical kinetics concepts can be the foundation for nutrient recommendations. Bioavailability experiments showed plasma and tissue concentrations were tightly controlled with oral administration of ascorbic acid. Reabsorption would be predicted in proximal renal tubules, concurrent with sodium-dependent vitamin C transporter1 localization. Accelerated ascorbic acid utilization in disease states may be a new frontier that can lead to discoveries for roles of ascorbic acid in disease treatment.
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Taylor & Francis
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2023
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