Bookshelf_NBK588732.pdf
In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative c...
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CABI
2023
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oapen-20.500.12657-63877 |
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oapen-20.500.12657-638772023-07-13T02:46:20Z Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance Edgington, Matthew P. Alphey, Luke gene drives; engineerd underdominance bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences In this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations. 2023-07-12T13:31:41Z 2023-07-12T13:31:41Z 2022 chapter 9781800621152 9781800621176 https://library.oapen.org/handle/20.500.12657/63877 eng application/pdf Attribution-NonCommercial-NoDerivatives 4.0 International Bookshelf_NBK588732.pdf CABI Transgenic Insects 10.1079/9781800621176.0012 10.1079/9781800621176.0012 acaa378d-268e-41be-97b3-f5dfd02ea3b2 f9945ef5-a5af-40fc-be6f-b50afee00ff1 d859fbd3-d884-4090-a0ec-baf821c9abfd 9781800621152 9781800621176 Wellcome 20 110117/Z/15/Z Wellcome Trust Wellcome open access |
| institution |
OAPEN |
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DSpace |
| language |
English |
| description |
In this chapter, we outline a range of
modelling approaches that have been used
to demonstrate the key characteristics of
this approach, including threshold introduction
frequencies, reversibility, spatial limitation
and robustness to mutation/resistance.
We then go on to discuss alternative configurations
based on the use of sex-specific
components and their effect on introduction
thresholds. We conclude with a discussion on the cycle of information between mathematical
models and experimental data along
with a range of areas for future modelling
that will be important in providing information
on the anticipated effects of these systems
when released into target populations. |
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Bookshelf_NBK588732.pdf |
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| title_sort |
bookshelf_nbk588732.pdf |
| publisher |
CABI |
| publishDate |
2023 |
| _version_ |
1799945192816508928 |
