Progress in medicinal chemistry. Volume 44 /
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R & D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease...
Άλλοι συγγραφείς: | , |
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Μορφή: | Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Amsterdam ; Boston :
Elsevier,
2006.
|
Σειρά: | Progress in Medicinal Chemistry ;
v. 44. |
Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Cover
- Preface
- Contents
- List of Contributors
- Finding Protein Kinase Hits using Structural Information
- Introduction
- Screening by X-ray Crystallography
- Screening by NMR
- Fundamentals of NMR Spectroscopy
- Using Chemical Shift Changes
- Nuclear-Spin Relaxation
- Nuclear Overhauser Effects
- Exchange Phenomena
- Applications of NMR in Screening
- Target-Based Screening
- Ligand-Based Screening
- Examples of NMR Methods for Discovering Kinase Inhibitors
- The Shapes Strategy
- NMR Screening by Waterlogsy Method
- NMR Screening of Protein Kinases by ATP-STD Method
- NMR Backbone Assignment of a Kinase
- Designing Novel Kinase Inhibitors from the NMR-Based Screening of Fragments
- Design of Libraries for use in NMR Screening
- In Silico Methods
- Receptor-Based Screening
- Compound Database and Receptor Preparation
- Protein-Ligand Docking
- Scoring Functions
- Development and Evaluation of Docking and Scoring
- Virtual Screening and Protein Kinases
- Faults and Fixes for Virtual Screening
- Consensus Scoring
- Knowledge-Based Screening
- Protein Flexibility and Induced Fit
- High Throughput Docking as a Virtual Screening Tool
- Alternatives to High Throughput Docking
- Comparative Homology Modelling
- De Novo Design
- Summary
- References
- Blunting the Swiss Army Knife of Hepatitis C Virus: Inhibitors of NS3/4A Protease*
- Hepatitis C Infection
- Introduction
- The Hepatitis C Virus
- Current Therapies for the Treatment of HCV Infections
- The HCV NS3/4A Protease
- Tools to Study NS3/4A Protease Inhibitors
- Enzymatic Assays
- Viral Replication
- Inhibitors of the NS3/4A Serine Protease
- Non-Covalent Peptidic Inhibitors
- Covalent Reversible Peptidic Inhibitors
- Non-Peptidic Inhibitors
- Summary and Outlook
- References
- Peptide Deformylase Inhibitors
- Introduction
- Peptide Deformylase as a Novel Antibacterial Target
- Function
- Essentiality
- Spectrum
- Selectivity
- Protein Structure of Peptide Deformylases
- Three-Dimensional Structure
- Metal-Binding Site
- Comparison with Other Metalloproteases
- Substrate-Binding Pockets
- Design and SAR of Peptide Deformylase Inhibitors
- Early Substrate-Based Inhibitors
- Pseudopeptidic Hydroxamic Acids and N-Formyl-N-Hydroxylamines
- Non-Peptidic Templates
- Clinical Candidates
- BB-83698
- LBM-415
- Summary and Perspectives
- Acknowledgements
- References
- Clinically Useful Vanilloid Receptor TRPV1 Antagonists: Just around the Corner (or too Early to Tell)?
- Introduction
- The Theory: Can TRPV1 Antagonists Function as Clinically useful Drugs? (The Pros and The Cons)
- TRPV1 Antagonists: an Overview of Chemistry and Pharmacology
- Iodinated Capsaicinoids and Resiniferonoids
- 4-Heteroarylpiperazine-1-Carboxyarylamides
- N-Arylcinnamides
- N-(Aza)naphthyl-N'-aryl(benzyl)ureas
- N-Aryl-N'-Alkylaminocarbonyl Ethylendiamines
- N, N'-Dibenzylthioureas
- Miscellaneous Natural and Endogenous Products
- Miscellaneous Structures from the Proprietary Literature
- Potential Clinical Indications for TRPV1 Blockade
- Chronic, Intractable Pa.