Mitochondrial function and dysfunction /

• Άλλοι συγγραφείς: Schapira, Anthony H. V. (Anthony Henry Vernon) (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; London : Academic Press, 2002.
• Σειρά: International review of neurobiology ; v. 53.
• Θέματα: Mitochondrial pathology.; Mitochondria.; Mitochondria > physiology.; Mitochondria > pathology.; Mitochondrial Diseases.; SCIENCE > Life Sciences > Cell Biology.; Electronic books.

 Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease. * Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction * Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases * Includes outstanding list of contributing authors. 

 Section I. Mitochondrial structure and function. Mitochondrial DNA structure and function / Carlos T. Moraes [and others]. Oxidative phosphoylation: structure, function, and intermediary metabolism / Simon J.R. Heales, Matthew E. Gegg, and John B. Clark. Import of mitochondrial proteins / Matthias F. Bauer, Sabine Hofmann, and Walter Neupert -- Section II. Primary respiratory chain disorders. Mitochondrial disorders of the nervous system: clinical biochemical, and molecular genetic features / Dominic Thyagarajan and Edward Byrne -- Section III. Secondary respiratory chain disorders. Friedrich's ataxia / J.M. Cooper and J.L. Bradley. Wilson's disease / C.A. Davie and A.H.V. Schapira. Hereditary spastic paraplegia / Christopher J. McDermott and Pamela J. Shaw. Cytochrome c oxidase deficiency / Giacomo P. Comi [and others] -- Section IV. Toxin-induced mitochondrial dysfunction / Susan E. Browne and M. Flint Beal -- Section V. Neurodegenerative disorders. Parkinson's disease / L.V.P. Korlipara and A.H.V. Schapira. Huntington's disease: the mystery unfolds? / Åsa Petersén and Patrik Brundin. Mitochondria in Alzheimer's disease / Russell H. Swerdlow and Stephen J. Kish. Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease / Mark P. Mattson. Mitochondria and amyotrophic lateral sclerosis / Richard W. Orrell and Anthony H.V. Schapira -- Section VI. Models of mitochondrial disease / Danae Liolitsa and Michael G. Hanna -- Section VII. Defects of [beta]-oxidation including carnitine deficiency / K. Barlett and M. Pourfarzam -- Section VIII. Mitochondrial involvement in aging. The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair / Nadja C. de Souza-Pinto and Vilhelm A. Bohr.