Progress in medicinal chemistry. Vol. 45 /
The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the pharmaceut...
| Άλλοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Amsterdam ; Oxford :
Elsevier,
2007.
|
| Έκδοση: | 1st ed. |
| Σειρά: | Progress in medicinal chemistry ;
45 |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Cover
- Progress in Medicinal Chemistry 45
- Copyright Page
- Contents
- Preface
- List of Contributors
- Chapter 1. Hit and Lead Identification: Efficient Practices for Drug Discovery
- Introduction
- Hit and Lead Identification Practices
- Lead Identification as Reported for Specific Targets
- Conclusion
- References
- Chapter 2. DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes
- Introduction
- Medicinal Chemistry and Preclinical Studies
- Clinical Data for Oral DPPIV Inhibitors
- Conclusions
- Authors Note
- References
- Chapter 3. Recent Progress Toward Nonpeptide Ligands for the Melanocortin-4 Receptor
- Introduction
- Cyclohexylpiperidines as Potent MC4R Agonists
- Cyclohexylpiperazines and Phenylpiperidines
- Phenylpiperazines as MC4R Agonists
- Other Classes of MC4R Agonists
- Compounds Mimicking a-MSH and its Peptide Analogues
- From Agonists to Antagonists
- Small Molecule MC4R Antagonists from Initial Screen Hits
- Other Nonpeptide MC4R Ligands
- Interaction of the MC4R with Ligands
- Medicinal Chemistry
- Conclusion
- References
- Chapter 4. Tuberculosis Chemotherapy: Recent Developments and Future Perspectives
- Introduction
- TB Drug Development Pipeline
- Potential New Drug Targets
- Concluding Comments
- Acknowledgments
- References
- Subject Index
- Author Index (Vols. 1- 45)
- Subject Index (Vols. 1- 45)
- Last Page.
