The neurobiology of epilepsy and aging /

Discusses all aspects of epilepsy in aging patients.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Ramsay, Eugene (Επιμελητής έκδοσης)
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Amsterdam ; Boston : Academic Press, ©2007.
Σειρά:International review of neurobiology ; v. 81.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Cover
  • Copyright Page
  • Dedication Page
  • Contents
  • Contributors
  • Acknowledgment
  • Chapter 1: Epilepsy in the Elderly: Scope of the Problem
  • I. Introduction
  • II. Known Knowns
  • A. Incidence and Prevalence of Epilepsy Is Higher in the Community-Dwelling Elderly Than in Younger Adults or Children
  • B. Prevalence and Incidence of Epilepsy Is Higher Among Nursing Home Residents Than Community-Dwelling Elderly
  • C. Retirement Age of 65 Is a Political Decision, Not Related to Medical Condition
  • D. The Elderly Are Not a Homogeneous Group
  • E. Patterns of AED Use Differ Markedly Between Countries and Between Community-Dwelling and Nursing Home Elderly
  • F. In Nursing Homes, the Young-Old are More Likely to Use an AED than the Old-Old
  • G. Causes of Epilepsy in the Elderly
  • H. Many Seizures in the Elderly are not Epileptic
  • I. AED Pharmacology Is Different in the Elderly
  • J. Choosing AEDs for an Elderly Person Is Difficult
  • K. Drug Interactions With Non-AEDs Are a Major Problem
  • III. Known Unknowns
  • IV. Unknown Unknowns
  • V. Unknown Knowns
  • A. The "Therapeutic" Range of Total Phenytoin is 10-20 mg/liter
  • B. AED Levels Are Stable Over Time With Constant Doses
  • VI. Conclusion
  • References
  • Chapter 2: Animal Models in Gerontology Research
  • I. Animal Models in Aging Research: Considerations for Experimental Design
  • II. The Age Factor
  • III. Genetic Background
  • IV. Choice of Strain
  • V. Environmental Influences
  • VI. Genomic Manipulations
  • VII. Resources
  • References
  • Chapter 3: Animal Models of Geriatric Epilepsy
  • I. Introduction
  • II. Mouse Models
  • A. Senescence-Accelerated Mouse
  • B. Cacnb4 (lh) Mouse
  • C. MTIII( -/- ) Mouse
  • D. El Mouse
  • E. DBA Mouse
  • F. Acute Seizure Models in Common Strains
  • III. Gerbil Model
  • IV. Rat Models
  • A. Acute Seizure Models
  • B. Lesion Models
  • C. Chronic Epilepsy Models
  • V. Conclusions
  • References
  • Chapter 4: Life and Death of Neurons in The Aging Cerebral Cortex
  • I. Introduction
  • II. Cortical Circuitry and Alzheimer's Disease
  • A. Overview
  • B. Hippocampal Pathology in AD
  • C. Neocortical Pathology in AD
  • D. Neurofilament Protein Is a Marker of Neuronal Vulnerability in AD
  • E. Summary: AD and Cortical Circuitry
  • III. AAMI: Functional Decline Without Neuron Loss
  • A. Introduction
  • B. The Aging Cerebral Cortex: Nonhuman Primate Studies
  • IV. Interactions Between Neural and Endocrine Senescence
  • V. Conclusions
  • Acknowledgments
  • References
  • Chapter 5: An In Vitro model of Stroke-Induced Epilepsy: Elucidation of the Roles of Glutamate and Calcium in the Induction and Maintenance of Stroke-Induced Epileptogenesis
  • I. Introduction
  • II. Role of Glutamate in the Pathophysiology of Stroke
  • III. Developing an In Vitro Model of Glutamate Injury That Causes a Mixed Population of Injured and Dead Neurons in Preparations of Hippocampal Neurons in Culture
  • IV. Development of SREDs in Neurons Surviving Injury
  • V. Neuronal Networks Di.