New transcription factors and their role in diabetes and therapy /

This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mec...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Friedman, Jacob E.
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Amsterdam ; Boston : Elsevier, 2006.
Έκδοση:1st ed.
Σειρά:Advances in molecular and cellular endocrinology ; v. 5.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • 1. PPARs as therapeutic targets for treating diabetes and insulin resistance
  • 2. Genetic regulators of human obesity and diabetes
  • 3. NF-kb, insulin resistance and the actions of salicylates
  • 4. Wnt signaling and C/EBPs role in adipogenesis
  • 5. Regulation of hepatic gluconeogenesis C/EPBs
  • 6. Forkhead proteins and regulation of hepatic gene expression
  • 7. Control of mitochondrial biogenesis through PGC-1
  • 8. Regulation of PGC-1 in humans in insulin resistance and diabetes: Functional implications
  • 9. FOXC2 controls resistance to obesity and Type II diabetes
  • 10. SREB-1C regulation of nutrient homeostasis and lipid accumulation
  • 11. GATA proteins as molecular gatekeeprs of the adipocyte
  • 12. Diabetes regulation of gene expression by CREB
  • 13. Molecular etiologies of MODY and other early-onset forms of diabetes
  • 14. Liver X receptors as potential drug targets for Diabetes and its disorders
  • 15. The potential therapeutic use of PPAR beta/delta agonists in lipid and glucose homeostasis
  • 16. Influences of new PPAR insulin sensitizers on the metabolic syndrome in Rhesus Monkeys
  • 17. PPARgamma and metabolism: Insights from the study of human genetic variants.
  • Transcription factor genes in type 2 diabetes / by M.N. Weedon, A.T. Hattersley & T.M. Frayling
  • PPAR[gamma], a key therapeutic target in the metabolic syndrome-unique insights derived from the study of human genetic variants / by C.S. Mitchell & M. Gurnell
  • PPAR[delta]: emerging therapeutic potential of novel agonists in lipid and glucose homeostasis / by U. Dressel & G.E.O. Muscat
  • Liver X receptors as potential drug targets for diabetes and its disorders / by K.R. Steffenson
  • SREBP-lc regulation of nutrient homeostasis and lipid accumulation / by P. Ferré [and others]
  • The adipocyte and adipose tissue as endocrine organs: impact on the insulin resistance phenotype / by R.R. Henry [and others]
  • FOXC2 in the adipocyte / by S. Enerbäck
  • Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors / by I. Gerin, H.D. Cha & O.A. MacDougald
  • GATA proteins as molecular gatekeepers of adipogenesis / by J. Tsai, Q. Tong & G.S. Hotamisligil
  • Forkhead proteins and the regulation of hepatic gene expression / by A. Barthel, S. Herzig & D. Schmoll
  • Disruption of CREB regulated of gene expression in diabetes / by J.E.B. Reusch, P.A. Watson & S. Pugazhenthi
  • Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: functional implications / by J. Pihlajamäki & M.E. Patti
  • Hepatic CCAAT/enhancer binding protein [beta] (C/EBP[beta]): engineer of diabetes, obesity, and inflammatory disease processes / by J.M. Schroeder-Gloeckler, S.M. Rahman & J.E. Friedman
  • Insulin resistance, inflammation, and the IKK/I[kappa]B/NF-[kappa]B pathway by B.A. Bhatt & R.M. O'Doherty.