HIV-1 : molecular biology and pathogenesis /

• Other Authors: Jeang, Kuan-Teh
• Format: eBook
• Language: English
• Published: Amsterdam ; Boston : Elsevier/Academic Press, ©2007.
• Series: Advances in pharmacology (San Diego, Calif.) ; 55.
• Subjects: HIV infections > Molecular aspects.; HIV infections > Pathogenesis.; HIV (Viruses); MEDICAL > AIDS & HIV.; HEALTH & FITNESS > Diseases > AIDS & HIV.; Electronic books.

This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.

Table of Contents:

• HIV-1 RNA Packaging
• Structure and Function of the HIV Envelope Glycoprotein as Entry Mediator, Vaccine Immunogen, and Target for Inhibitors
• HIV-1 Reverse Transcription: Close Encounters Between the Viral Genome and a Cellular tRNA
• Transcription of HIV: Tat and Cellular Chromatin
• Posttranscriptional Control of HIV-1 and Other Retroviruses and Its Practical Applications
• HIV Accssory Genes Vif and Vpu
• Interactions of HIV-1 Viral Protein R with Host Cell Proteins
• HIV-1 Protease: Structure, Dynamics, and Inhibition
• Properties, Functions, and Drug Targeting of the Multifunctional Nucleocapsid Protein of the Human Immunodeficiency Virus
• Human Immunodeficiency Virus Type 1 Assembly, Release, and Maturation
• Role of Nef in HIV-1 Replication and Pathogenesis
• Treatment Implications of the Latent Reservior for HIV-1
• RNA Interference and HIV-1.