Advances in immunology. Volume 91 /

• Άλλοι συγγραφείς: Alt, Frederick W.
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Diego, CA : Elsevier Science & Technology, 2006.
• Σειρά: Advances in immunology ; v. 91.
• Θέματα: Immunology.; Electronic books.

 Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. 

 Cover -- Cover Page -- Title Page -- Copyright Page -- Contents -- Contributors -- Chapter 1: A Reappraisal of Humoral Immunity Based on Mechanisms of Antibody-Mediated Protection Against Intracellular Pathogens -- 1. Introduction -- 2. Intracellular and Extracellular Pathogenic Microbes: How Distinct Are They? -- 3. Components of AMI -- 4. AMI in the Context of the "Damage-Response Framework" -- 5. Abs as Enhancers of Innate Immunity -- 6. Abs as Direct and Indirect Effector Molecules -- 7. AMI as a Regulator of the Inflammatory Response -- 8. Dose-Response Conundrum -- 9. Ab-Mediated Protection Against Intracellular Pathogens -- 10. Protective Efficacy of an Ab Molecule -- 11. Some Emerging Concepts -- Acknowledgments -- References -- Chapter 2: Accessibility Control of V(D)J Recombination -- 1. Introduction -- 2. V(D)J Recombination: A Mechanistic Perspective -- 3. Genomic Architecture of Ig and TCR Loci -- 4. Regulation of Antigen Receptor Gene Assembly During Lymphocyte Development -- 5. Regulation of V(D)J Recombination: The Accessibility Hypothesis and Beyond -- 6. Chromatin Structure and Accessibility Control Mechanisms -- 7. Regulation of Antigen Receptor Loci by Nuclear Topography -- 8. Regulation of Chromatin Accessibility and V(D)J Recombination by Cis-Acting Elements -- 9. Role of Transcription in Accessibility Control of V(D)J Recombination -- 10. Transcription Factors Involved in Accessibility Control of Ig and TCR Loci -- 11. Control of Recombinase Accessibility by Chromatin Modifications and Remodeling -- 12. Concluding Remarks -- Acknowledgments -- References -- Chapter 3: Targeting Integrin Structure and Function in Disease -- 1. Introduction -- 2. Structure, Ligand-Binding Sites, and Competitive Antagonists -- 3. Large Conformational Changes and Affinity States -- 4. I-Domain Allosteric Site and Antagonists -- 5. An Internal Ligand -- 6. betaI-Domain Allosteric Regulation -- 7. The PSI- and EGF-Domain Restraints -- 8. The Cytoplasmic Domain Restraint -- 9. Therapeutics -- 10. Concluding Remarks -- Acknowledgments -- References -- Chapter 4: Endogenous TLR Ligands and Autoimmunity -- 1. Introduction (Short Overview on TLR Immunobiology) -- 2. The Innate: Adaptive Immune Connection -- 3. TLR-Mediated Immunostimulatory Potential of Self-RNA and -DNA -- 4. Function of IFN-alpha/beta -- 5. Cytokine-Driven DC Activation: A Portal for Autoimmunity? -- 6. TLRs and Autoimmunity -- 7. TLRs and "Innate Autoimmunity" -- Acknowledgments -- References -- Chapter 5: Genetic Analysis of Innate Immunity -- 1. Introduction -- 2. How Do We Detect Infection? -- 3. Forward and Reverse Genetic Analyses of TLR Signaling -- 4. TLR-Independent Detection of Microbes -- 5. Global Resistome -- 6. Endogenous Activators of TLR Signaling? -- 7. Conclusions About Innate Immunity and the Classical Genetic Approach -- Acknowledgments --t.