Chondroitin Sulfate : Structure, Role and Pharmacological Activity /

• Άλλοι συγγραφείς: Volpi, Nicola (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Elsevier, 2006.
• Σειρά: Advances in pharmacology (San Diego, Calif.) ; v. 53.
• Θέματα: Proteoglycans.; Glycosaminoglycans.; Dermatan sulfate.; Pharmacy > Research.; Chondroitin Sulfates.; SCIENCE > Life Sciences > Biochemistry.; MATHEMATICS > Calculus.; MATHEMATICS > Mathematical Analysis.; Electronic books.

 CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade. 

 Cover -- Title Page -- Serial Editors -- Copyright Page -- Contents -- Abbreviations -- Contributors -- Preface -- Part I Structure -- Chapter 1: Isolation, Purification, and Analysis of Chondroitin Sulfate Proteoglycans -- I. Chapter Overview -- II. Introduction -- III. Preparation of Tissues for CSPGs Extraction -- IV. Extraction of CSPGs -- V. Isolation and Purification of CSPGs -- VI. Structural Analyses of CSPGs -- VII. Conclusions -- Acknowledgments -- References -- Chapter 2: Isolation and Purification of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. General Characteristics of CS -- IV. Sources and Structure of Commercial Forms of CS -- V. General Preparative Procedures to Extract CS from Tissues -- VI. Extraction from Tissues -- VII. Recovery of CS from Proteinase Extracts -- VIII. Fractionation Methods -- IX. Conclusions -- Acknowledgments -- References -- Chapter 3: Structure of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. Linkage Region -- IV. Repeating Disaccharide Region -- V. Nonreducing Terminal -- VI. Future Perspectives -- References -- Chapter 4: Progress in the Structural Biology of Chondroitin Sulfate -- I. Chapter Overview -- II. Introduction -- III. Experimental Structures of CS Chains -- IV. Theoretical Studies -- V. NMR Studies of CS and DS Polysaccharides -- VI. Structures of CS Proteoglycans -- VII. Chondroitin as a Covalent Cross-Link Between Two or More Proteins -- VIII. Crystal Structures of Complexes Between Chondroitin Degrading Enzymes and Oligosaccharides -- IX. Specificity of Interactions Between Chondroitin Sequences and Proteins -- References -- Chapter 5: The Biosynthesis and Catabolism of Galactosaminoglycans -- I. GalAG Biopolymers -- II. GalAGs in the Extracellular Matrix -- III. GalAG-Protein Interactions -- IV. GalAGs in Biomedicine -- V. The Biosynthesis of GalAGs -- VI. The Catabolism of GalAGs -- VII. The Enzymatic Degradation of GalAGs -- VIII. Perspectives -- References -- Chapter 6: Biosynthesis of Chondroitin Sulfate: From the Early, Precursor Discoveries to Nowadays, Genetics Approaches -- I. Chapter Overview -- II. Introduction -- III. Precursor Discoveries on the Biosynthesis of CS -- IV. The Biosynthesis of the CS Starts with the Formation of the Linkage Region -- V. Post-Translational Modifications of the Linkage Region Regulate the Synthesis of the GAG chain -- VI. Chain Initiation and Polymerization of CS/DS -- VII. Sulfation of CS: General Properties of the Sulfotransferases -- VIII. 6-O-Sulfotransferase -- IX. 4-O-Sulfotransferase -- X. 2-O-Sulfotransferase -- XI. Genetic Defects Affecting the Biosynthesis of CS -- XII. Future Perspectives -- References -- Chapter 7: Advances in the Analysis of Chondroitin/Dermatan Sulfate -- I. Chapter Overview -- II. Introduction -- III. Chromogenic Quantitative Methods -- IV. Chromatographic Methods -- V. Electromigration Methods -- VI. Solid Phase Assays, ELISA and ELISA-Based Procedures -- VII. General Conclusions -- Ackn.