The Neurobiology of Hyperthermia /

• Άλλοι συγγραφείς: Sharma, H. S. (Hari Shanker) (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Elsevier, 2007.
• Έκδοση: First edition.
• Σειρά: Progress in brain research ; v. 162.
• Θέματα: Heat > Physiological effect > Research.; Central nervous system > Effect of heat on.; Thermotherapy > Research.; Neurobiology.; MEDICAL > Neuroscience.; PSYCHOLOGY > Neuropsychology.; Electronic books.

 The effects of global warming on human health factors with special regards to our brain function are still not well understood. There is an urgent need to expand our knowledge on the effects of hot environment on our brain functions in healthy and in diseased populations. It is still unclear whether infectious events, traumatic injuries, metabolic diseases, carcinogenic events, cardiovascular and respiratory functions will be adversely affected by the rise in global temperature or whether environmental pollutants, such as nanoparticles entered into our body system will produce more damage at higher temperatures. 

 Cover -- Copyright page -- List of Contributors -- Preface -- Contents -- Section I: Fever and Hyperthermia -- Chapter 1. The onset of fever: new insights into its mechanism -- Introduction -- Pyrogen activation of the brain: the role of the vagus -- PGE2, not cytokines, is the peripheral fever trigger -- Contribution of preoptic PGE2 to fever production -- Conclusions -- Acknowledgments -- References -- Chapter 2. Eicosanoids in non-febrile thermoregulation -- Introduction -- Prostaglandins -- Leukotrienes and other lipoxygenase products of AA -- Conjugates of AA -- Conclusions -- Abbreviations -- Acknowledgments -- References -- Section II: Physiological Mechanisms in Hyperthermia -- Chapter 3. Exercise and heat stress: cerebral challenges and consequences -- Introduction: the hot and hard working brain -- Central fatigue and critical internal temperatures -- Cerebral thermodynamic responses during exercise -- Cerebral blood flow and metabolism -- Neurohumoral responses in relation to hyperthermia-induced fatigue -- Conclusions -- Abbreviations -- References -- Chapter 4. Neuropsychological determinants of exercise tolerance in the heat -- Introduction -- Neuropsychological responses to hyperthermia -- Heat stress countermeasures -- Summary -- Acknowledgments -- References -- Section III: Drugs and Hyperthermia -- Chapter 5. Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human -- Introduction -- Thermoregulatory profile and hyperthermic efficacy of drugs -- Ambient temperature and potential hyperthermic response -- Patterns of drug toxicity as function of temperature -- Extrapolating from rodent to human -- Methylenedioxymethamphetamine (MDMA) -- Interaction between hyperthermia and drug toxicity -- Reactive oxygen species (ROS) -- Conclusions -- Acknowledgements -- References -- Chapter 6. Neuroleptic malignant syndrome and serotonin syndrome -- Introduction -- Neuroleptic malignant syndrome -- Serotonin syndrome -- References -- Section IV: Therapeutic Hyperthermia and Consequences -- Chapter 7. Radio frequency electromagnetic fields: mild hyperthermia and safety standards -- Introduction -- Dosimetry of radio frequency electromagnetic fields -- Thermoregulation2 -- Behavioral effects of RF-EMF exposure -- Basis of safety standards -- Conclusions -- Disclaimer -- References -- Chapter 8. The effect of induced hyperthermia on the immune system -- Introduction -- Basic effects of hyperthermia -- Effects of heat on the immune system -- Lymphocyte apoptosis as part of immune regulation and putative effect of therapeutical hyperthermia -- Conclusion -- References -- Chapter 9. Cerebral pathophysiology and clinical neurology of hyperthermia in humans -- Introduction -- Therapeutic hyperthermia in humans -- Fever in neurologically injured patients -- Conclusions -- Abbreviations -- References -- Section V: Hyperthermia and Brain Pathology -- Chapter 10. Methods to produce hyperthermia-induced brain dysfunction -- Introduction -- Model of whole-body hyperthermia -- Conclusion -- Acknowledgments --T$1.