Regulators and effectors of small GTPases : Rho family /

• Άλλοι συγγραφείς: Balch, William Edward, 1949-, Der, Channing J., Hall, A. (Alan)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Elsevier : Academic Press, Ã2006.
• Σειρά: Methods in enzymology ; v. 406.
• Θέματα: Guanosine triphosphatase.; Rho GTPases.; SCIENCE > Life Sciences > Molecular Biology.; GTPasen.; Regelmechanismen.; Rab-Proteine; Rho-Proteine; rho GTP-Binding Proteins > physiology.; Electronic books.
• Φυσική περιγραφή: 1 online resource (xliii, 798 pages) : illustrations.
• Βιβλιογραφία: Includes bibliographical references and indexes.
• ISBN: 0080479391; 9780080479392; 0121828115; 9780121828110
• ISSN: 0076-6879 ;

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua.