Functional genomics and proteomics in the clinical neurosciences /

• Άλλοι συγγραφείς: Hemby, S. E. (Επιμελητής έκδοσης), Bahn, Sabine (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Elsevier, 2006.
• Έκδοση: 1st edition.
• Σειρά: Progress in brain research ; v. 158.
• Θέματα: Neurobehavioral disorders > Genetic aspects.; Neurobehavioral disorders > Molecular aspects.; Messenger RNA > Analysis.; Proteins > Analysis.; Gene expression > Research.; Genomics.; Proteomics.; Neurogenetics.; Nervous System Diseases > genetics.; Genomics > methods.; Proteomics > methods.; Neurogénétique > Méthodologie.; Protéomique > Méthodologie.; Système nerveux > Maladies > Aspect génétique.; HEALTH & FITNESS > Diseases > General.; MEDICAL > Clinical Medicine.; MEDICAL > Diseases.; MEDICAL > Evidence-Based Medicine.; MEDICAL > Internal Medicine.; Genomica.; Proteomica.; Neurowetenschappen.; Electronic books.

The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both...

Πίνακας περιεχομένων:

• Section I: Methodologies
• Tissue preparation and banking
• Functional genomic methodologies
• Methods for proteomics in neuroscience
• Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics
• Reproducibility of microarray studies: concordance of current analysis methods
• Introduction
• Section II: Applications of Genomics and Proteomic Technologies to Clinical Neuroscience
• The genomics of mood disorders
• Assessment of genome and proteome profiles in cocaine abuse
• Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease
• Epileptogenesis-related genes revisited
• Functional genomics of sex hormone-dependent neuroendocring systems: specific and generalized actions in the CNS
• Section III: Future Directions
• Implications for the practice of psychiatry
• Human brain evolution.