Structure, function and regulation of Tor complexes from yeasts to mammals. Part A /

• Άλλοι συγγραφείς: Hall, Michael N., Tamanoi, Fuyuhiko
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Academic Press, 2010.
• Έκδοση: 1st ed.
• Σειρά: Enzymes ; v. 27.
• Θέματα: Rapamycin.; Immunosuppressive agents.; Sirolimus.; Immunosuppressive Agents.; TOR Serine-Threonine Kinases.; MEDICAL > Biochemistry.; Electronic books.

 Cell growth is highly regulated and is controlled by the TOR signaling network. Dysfunction of signaling pathways controlling cell growth results in cells of altered sizes and in turn causes developmental errors and a wide range of pathological conditions. An understanding of the TOR signaling network may lead to novel drugs for the treatment of, for example, €cancer, diabetes, inflammation, muscle atrophy, learning disabilities, depression, obesity and aging. There has been an explosion of knowledge in this area in recent years and this volume provides an in-depth review of our current knowledge of TOR complexes by the leadersin the field. 

 TOR Complexes: Composition, Structure, and Phosphorylation -- Regulation of TOR Signaling in Mammals -- Rheb G-Proteins and the Activation of mTORC1 -- Regulation of TOR Complex 1 by Amino Acids Through Small GTPases -- Rag GTPases in TORC1 Activation and Nutrient Signaling -- Amino Acid Regulation of hVps34 and mTORC1 Signaling -- AGC Kinases in mTOR Signaling -- mTORC1 and Cell Cycle Control -- TORC1 Signaling in Budding Yeast -- TORC2 and Sphingolipid Biosynthesis and Signaling: Lessons from Budding Yeast -- TORC1 Signaling in the Budding Yeast Endomembrane System and Control of Cell-Cell Adhesion in Pathogenic Fungi -- TOR and Sexual Development in Fission Yeast -- Fission Yeast TOR and Rapamycin -- Structure of TOR Complexes in Fission Yeast -- Stucture of TOR Complexes in Fission Yeast -- The TOR Complex and Signaling Pathway in Plants -- Dysregulation of TOR Signaling in Tuberous Sclerosis and Lymphangioleiomyomotosis -- Chemistry and Pharmacology of Rapamycin and Its Derivatives.