Developmental neurotoxicology research : principles, models, techniques, strategies, and mechanisms /

• Κύριος συγγραφέας: Wang, Cheng, 1954-
• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Άλλοι συγγραφείς: Slikker, William, Jr
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : Wiley, [2011]
• Θέματα: Neurotoxicology.; Developmental toxicology.; Nervous System > drug effects.; Nervous System > growth & development.; Neurotoxicity Syndromes > etiology.; HEALTH & FITNESS > Diseases > Nervous System (incl. Brain); MEDICAL > Neurology.; Electronic books.

 This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research. 

 Section I: Models, Approaches, and Challenges in Neurotoxicity Research during Development. Part Introduction / Tucker A Patterson -- Approaches and Models for Evaluating the Toxic Effects of Anesthetics in the Developing Nervous System / William Slikker, Xuan Zhang, Fang Liu, Merle G Paule, Cheng Wang -- Systems Biology Approaches to Neurotoxicity Studies during Development / Tucker A Patterson, Bradley J Schnackenberg, William Slikker, Cheng Wang -- Behavioral Approaches for Assessing Nervous System Function during Development in Animal Models / Merle G Paule -- Applications of Unbiased Stereology to Neurodevelopmental Toxicology / Peter R Mouton -- Section II: Effects of Anesthetics and their Potential Neurotoxicity during Development. Part Introduction / Xuan Zhang, William Slikker -- Neurotoxic Effects of Anesthetics and Potential Protective Agents / Xuan Zhang, Tucker A Patterson, Merle G Paule, William Slikker, Cheng Wang -- Perinatal Rhesus Monkey Models and Anesthetic-Induced Neuronal Cell Death / William Slikker, Fang Liu, Xuan Zhang, Xiaoju Zou, Tucker A Patterson, Merle G Paule, Cheng Wang -- Effects of Gaseous Anesthetic Combinations during Development / Vesna Jevtovic-Todorovic -- Perinatal Anesthetic Administration and Short-Long-Term Behavioral Deficits / Vesna Jevtovic-Todorovic -- Section III: The Developmental Basis of Adolescent or Adult Disease. Part Introduction / Jerrold J Heindel -- Developmental Lead Exposure, Epigentics and Late Onset Alzheimer's Disease / Nasser H Zawia, Riyaz Basha -- Developmental Trajectories of Autism and Environmental Exposures--What We Know and Where We Need to Go / Cindy P Lawler, Alycia Halladay -- Actions of Manganese on Pubertal Development / W Les Dees, Jill K Hiney, Vinod K Srivastava -- Exposure of the Developing Brain to Polychlorinated Biphenyls Influences the Susceptibility of the Adult Brain to Stress / Pamela J Lein, Kyung Ho Kim, Robert F Berman, Isaac N Pessah -- A Neurodevelopmental Origin for Pakinson's Disease: A Link to the Fetal Basis for Adult Disease Hypothesis / D Urbach-Ross, M Thiruchelvam -- Genetic and Environmental Factors in Attention-Deficit Hyperactivity Disorder / Angela A Baker, Michele M Taylor, Jason R Richardson -- Section IV: Risk Assessment of Methyl Mercury and Its Effects on Neurodevelopment. Part Introduction / Michael Aschner -- Fish Nutrients and Methylmercury: A View from the Laboratory / M Christopher Newland -- Neurodevelopmental Effects of Maternal Nutrition Status and Exposure to Methyl Mercury from Eating Fish during Pregnancy: Evidence from the Seychelles Child Development Study / Philip W Davidson, J J Strain, Gary J Myers, Conrad F Shamlaye, Sally Thurston, Maxine P Bonham, Emeir M Duffy, Julie M W Wallace, Gene Watson, Thomas W Clarkson -- Methylmercury Neurotoxicology: From Rare Poisonings to Silent Pandemic / Philippe Grandjean, Anna L Choi, Pal Weihe, Katsuyuki Murata -- Oxidative Stress and Methylmercury-Induced Neurotoxicity / Marcelo Farina, Jôo Batista Teixeira Rocha, Michael Aschner -- Learning Deficits and Depressionlike Behaviors Associated with Developmental Methylmercury Exposures / Natalia Onishchenko, Sandra Ceccatelli -- Methylmercury Effects on Neural Developmental Signaling Pathways / Matthew D Rand -- Section V: Autism Spectrum Disorders. Part Introduction / Isaac N Pessah -- Neurodevelopmental Toxicology and Autism Spectrum Disorders / Robert F Berman, Claire M Koenig, Michael R Hunsaker, Isaac N Pessah, Janine M Lasalle -- Redox Imbalance and the Metabolic Pathology of Autism / Richard Deth, Mostafa Waly, Christina Muratore, Nathaniel Hodgson -- Neuroinflammation and Autism / G Jean Harry -- Autism, Peripheral Immunity, and Polybrominated Diphenyl Ethers / Paula Goines, Paul Ashwood, Judy Van de Water -- An Emerging Gene₆Environment Interaction Model: Autism Spectrum Disorder Phenotypes Resulting from Exposure to Environmental Contaminants during Gestation / Darryl B Hood, Daniel Campbell, Pat Levitt -- Section VI: Strategies and Progress in Epilepsy Research. Part Introduction / Merle G Paule -- Neonatal Seizures / Reňe A Shellhaas -- Experimental Models of Epileptogenesis / Hana Kubov̀ -- Effect of Seizures on the Developing Brain: Lessons from the Laboratory / Shaun Hussain, Raman Sankar.