Glycosaminoglycans in Development, Health and Disease /

• Άλλοι συγγραφείς: Zhang, Lijuan (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam ; Boston : Academic, 2010.
• Σειρά: Progress in molecular biology and translational science ; v. 93.
• Θέματα: Glycosaminoglycans.; Heparin.; Glycomics.; Glycosaminoglycans > Physiological effect.; Natural history.; Science.; MEDICAL > Pharmacology.; Electronic books.

 Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials including heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. 

 Glycosaminoglycan (GAG) Biosynthesis and GAG-Binding Proteins -- Mice Deficient in Glucuronyltransferase-I -- Mice Deficient in Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1 -- Glucuronyl C5-Epimerase -- Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1 -- The Roles of Chondroitin-4-Sulfotransferase-1 in Development and Disease -- Roles of Heparan Sulfate in Mammalian Brain Development: Current Views Based on the Findings from Ext1 Conditional Knockout Studies -- Anticoagulant Heparan Sulfate -- Endothelial Heparan Sulfate in Angiogenesis -- Hepatic Heparan Sulfate Proteoglycans and Endocytic Clearance of Triglyceride-Rich Lipoproteins -- Serglycin Proteoglycan Deletion in Mouse Platelets: Physiological Effects and Their Implications for Platelet Contributions to Thrombosis, Inflammation, Atherosclerosis, and Metastasis -- Congenital Disorders of Glycosylation with Emphasis on loss of Dermatan-4-Sulfotransferase -- Heparan Sulfate Proteoglycans in Amyloidosis -- Heparin as an Inhibitor of Cancer Progression -- Diverse Functions of Glycosaminoglycans in Infectious Diseases -- Molecular Mechanism Underlines Heparin-Induced Thrombocytopenia and Thrombosis -- Chondroitin Sulfate and Abnormal Contact System in Rheumatoid Arthritis -- Activated Contact System and Abnormal Glycosaminoglycans in Lupus and other Auto- and Non-Autoimmune Diseases -- Glycosaminoglycans and Activated Contact System in Cancer Patient Plasmas.