ADMET for medicinal chemists : a practical guide /

• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Άλλοι συγγραφείς: Tsaioun, Katya, Kates, Steven A., 1961-
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2011]
• Θέματα: Drugs > Testing.; Drug Design.; Drug Toxicity.; Pharmaceutical Preparations > chemistry.; Pharmacokinetics.; Drugs > Testing > Juvenile literature.; JUVENILE NONFICTION > General.; Electronic books.

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strat...

Πίνακας περιεχομένων:

• In silico ADME/tox predictions / David Lagorce [and others]
• Absorption and physicochemical properties of the NCE / Jon Selbo and Po-Chang Chiang
• ADME / Martin E. Dowty [and others]
• Pharmacokinetics for medicinal chemists / Leo Kirkovsky and Anup Zutshi
• Cardiac toxicity / Ralf Kettenhofen and Silke Schwengberg
• Genetic toxicity : in vitro approaches for medicinal chemists / Richard M. Walmsley and David Elder
• Hepatic toxicity / Jinghai James Xu and Keith Hoffmaster
• In vivo toxicological considerations / John P. Devine Jr.
• Pre-clinical candidate nomination and development / Nils Bergenhem
• Fragment-based drug design : considerations for good ADME properties / Haitao Ji.