Cardiovascular pharmacology : endothelial control /

• Άλλοι συγγραφείς: Vanhoutte, Paul M.
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Diego : Academic Press, Ã2010.
• Έκδοση: 1st ed.
• Σειρά: Advances in pharmacology (San Diego, Calif.) ; v. 60.
• Θέματα: Cardiovascular agents.; MEDICAL > Pharmacology.; Cardiovascular Agents.; Cardiovascular Diseases > drug therapy.; Endothelium, Vascular.; Electronic books.

 Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions This volume contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field. 

 Cover13; -- Cardiovascular Pharmacology: Endothelial Control -- Copyright Page -- Contents -- Contributors -- Foreword -- Chapter 1: The Cardiovascular Physiology and Pharmacology of Endothelin-1 -- I. Introduction -- II. Cardiovascular Physiology of ET-1 -- III. Conclusion -- Acknowledgments -- References -- Chapter 2: Vascular Pharmacology of Epoxyeicosatrienoic Acids -- I. Introduction -- II. Biochemistry -- III. EETs and Vascular Tone -- IV. EETs and Inflammation -- V. EETs and Angiogenesis -- VI. Conclusion -- Acknowledgment -- References -- Chapter 3: Prostaglandins in Action -- I. Introduction -- II. COX Isozymes -- III. COX-1 and COX-2 in Patho/Physiological States -- IV. Controversies over COX-2 Inhibitors and Cardiovascular Events -- V. Conclusion -- Acknowledgments -- References -- Chapter 4: TP Receptors and Oxidative Stress -- I. Introduction -- II. Arachidonic Acid Derivatives and Oxidative Stress -- III. Vascular Function -- IV. Vascular Inflammation -- V. Atherosclerosis -- VI. Implications for Clinical Usefulness of TP Antagonists -- Acknowledgments -- References -- Chapter 5: Regulation of Endothelial Cell Tetrahydrobiopterin -- I. Introduction -- II. Chemistry and Synthesis of Pterins -- III. The Role of BH4 in NOS Function & mdash;Concept of NOS Uncoupling -- IV. NOS Uncoupling in Diseases -- V. Structural Characteristics of GTPCH-1 and Posttranslational Modulation -- VI. Conclusion -- Acknowledgments -- References -- Chapter 6: Polyphenol-Induced Endothelium-Dependent Relaxations -- I. Introduction: The Epidemiological Evidence -- II. Polyphenols Induce Endothelium-Dependent Responses In Vitro and Ex Vivo -- III. Polyphenols and Endothelial Function In Vivo -- IV. Conclusion -- References -- Chapter 7: Organic Nitrates and Nitrate Tolerance & mdash;State of the Art and Future Developments -- I. Introduction -- II. The Phenomenon of Nitrate Tolerance -- III. Oxidative Stress -- IV. Bioactivation of Organic Nitrates -- V. Strategies to Overcome Nitrate Tolerance -- VI. New Nitrates -- VII. Conclusion, Outlook, and Clinical Relevance -- Acknowledgments -- References -- Chapter 8: Vascular Actions of Adipokines -- I. Introduction -- II. Cross-Talk Between Adipose Tissue and Blood Vessels -- III. Modulation of Vascular Function by Adipokines -- IV. Adiponectin and A-FABP as Therapeutic Targets for Vascular Diseases -- V. Conclusion -- Acknowledgments -- References -- Chapter 9: Cardiovascular Effects of Erythropoietin -- I. Introduction -- II. Pharmacokinetics of Erythropoietin -- III. Signal Transduction by Erythropoietin -- IV. Mechanisms of Vascular Protective Effects of Erythropoietin -- V. Erythropoietin and Cardioprotection -- VI. Erythropoietin and Cerebrovascular Disorders -- VII. Erythropoietin and Progenitor Cells -- VIII. Conclusion -- Acknowledgments -- References -- Index -- Contents of Previous Volumes.