Development, Differentiation and Disease of the Para-Alimentary Tract /

• Άλλοι συγγραφείς: Kaestner, Klaus (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amesterdam ; Boston : Elsevier Academic Press, 2010.
• Σειρά: Progress in molecular biology and translational science ; v. 97.
• Θέματα: Alimentary canal.; SCIENCE > Life Sciences > Human Anatomy & Physiology.; MEDICAL > Anatomy.; Electronic books.

 Understanding how digestive organs develop, their physiology and structure is important for determining new therapies to combat diseases of the digestive organs. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields. 

 Cover13; -- Progress in Molecular Biology and Translational Science: Development, Differentiation and Disease of the Para-Alimentary Tract -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: Transcriptional Control of Acinar Development and Homeostasis -- I. Introduction -- II. Formation of the Multipotent Progenitor Cell (MPC) Population -- III. Transcriptional Induction of Acinar Cell-Fate and the Onset of Differentiation -- IV. Acinar Cell Differentiation -- V. Transcriptional Control of the Maintenance, Self-Renewal and Plasticity of Acinar Cells -- Acknowledgement -- References -- Chapter 2: Molecular Biology of Pancreatic Ductal Adenocarcinoma Progression -- I. Introduction -- II. Anatomy of the Exocrine Pancreas -- III. Development of the Exocrine Pancreas -- IV. Genetic Alterations in PDAC -- V. Activation of Developmental Pathways Driving Cancer Progression -- VI. Concluding Remarks -- References -- Chapter 3: Transcriptional Control of Hepatocyte Differentiation -- I. Overview of Liver Development -- II. Transcription Factors Controlling Hepatic Competence of the Definitive Endoderm -- III. Specification of Competent Endoderm Cells into Hepatoblasts and Expansion of the Liver Bud -- IV. Differentiation of Hepatoblasts into Hepatocytes -- V. Transcriptional Networks Define Maturation of Hepatocytes -- VI. Conclusion -- References -- Chapter 4: Molecular Mechanisms of Biliary Development -- I. Introduction -- II. Morphogenesis of the Intrahepatic Bile Ducts -- III. Signaling Mechanisms Controlling Cholangiocyte Differentiation and Biliary Tubulogenesis -- IV. Transcriptional Regulation of Biliary Differentiation -- V. Transcriptional Regulation of Biliary Tubulogenesis -- VI. Regulation of Biliary Development by MicroRNAs -- VII. Development of the Extrahepatic Biliary Tree -- VIII. Conclusions -- Acknowledgments -- References -- Chapter 5: Molecular Determinants of Liver Zonation -- I. Introduction -- II. The Concept of Liver Zonation -- III. The Wnt/beta-Catenin ''Zonation-Keeper180;180; Pathway -- IV. The Control of a Zone-Specific Transcription by beta-Catenin -- V. Future Prospects and Conclusion -- Acknowledgments -- References -- Chapter 6: Fibrosis in the Liver -- I. Clinical Impact -- II. Patterns of Fibrosis Progression -- III. Fibrogenic Stimuli -- IV. Extracellular Matrix -- V. Cellular Sources of ECM -- VI. Fibrosis-Related Receptors and Signaling Pathways -- VII. Disease-Specific Mechanisms of Hepatic Fibrogenesis -- VIII. Genetic Determinants of Hepatic Fibrosis -- IX. Reversibility of Hepatic Fibrosis and Cirrhosis -- References -- Chapter 7: Hierarchies of Transcriptional Regulation During Liver Regeneration -- I. Introduction: Models and Applications of Liver Regeneration -- II. Preexisting Transcription Factors Dominate During the Early Response to Partial Hepatectomy -- III. Nuclear Receptors and De Novo Synthesized Transcription Factors Control Cell Proliferation During Liver Regeneration -- IV. Termination of Liver Regeneration and Liver Size Adjustment -- V. Conclusions: Recent Progress and Significance of Molecular Mechanisms Controlling Liver Regeneration -- References -- Chapter 8: Biology of the Adult Hepatic Progenitor Cell -- I. Introduction: The Oval Cell -- II. Canals of Hering: The Putative Oval Cell Niche -- III. Oval Cell-Mediated Liver Regeneration -- IV. Molecular Regulation of the Oval Cell Res.