Label-free technologies for drug discovery /

• Άλλοι συγγραφείς: Cooper, M. A. (Matthew A.), Mayr, Lorenz
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Chichester, West Sussex, U.K. : John Wiley & Sons, 2011.
• Θέματα: Drug development.; Drug Discovery.; Biosensing Techniques.; Drug Design.; Medicine.; Pharmacy.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Electronic books.

 Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plat. 

 Front Matter -- The Revolution of Real-Time, Label-Free Biosensor Applications / Rebecca L Rich, David G Myszka -- Design and Implementation of Vertically Emitting Distributed Feedback Lasers for Biological Sensing / Meng Lu, Steven S Choi, Chun Ge, Clark J Wagner, J Gary Eden, Brian T Cunningham -- SPR Screening of Chemical Microarrays for Fragment-Based Discovery / Thomas Neumann, Renate Sekul -- The CellKeyʼ System: A Label-Free Cell-Based Assay Platform for Early Drug Discovery Applications / Ryan P McGuinness, Debra L Gallant, Yen-Wen Chen, Trisha A Tutana, Donna L Wilson, John M Proctor, H Roger Tang -- Dynamic and Label-Free Cell-Based Assays Using the xCELLigence System / Yama A Abassi, Alexander Sieler, Manfred Watzele, Xiaobo Wang, Xiao Xu -- Selecting the Best HTS Hits to Move Forward: ITC Ligand Binding Characterization Provides Guidance / Ronan O'Brien, Richard Brown -- Incorporating Transmitted Light Modalities into High-Content Analysis Assays / Robert Graves -- Nonradioactive Rubidium Efflux Assay Technology for Screening of Ion Channels / Georg C Terstappen -- Expanding the Scope of HTMS Methods / Tom G Holt, Jun Wang, Xun Chen, Bernard K Choi, Neil S Geoghagen, Kristian K Jensen, Maxine Jonas, Qi Luo, William A LaMarr, Lorraine Malkowitz, Can C Ozbal, Yusheng Xiong, Claude Dufresne, Ming-Juan Luo -- A Novel Multiplex SPR Array for Rapid Screening and Affinity Determination of Monoclonal Antibodies: The ProteOn XPR36 Label Free System: Kinetic Screening of Monoclonal Antibodies / Vered Bronner, Oded Nahshol, Tsafrir Bravman -- Biophysics/Label-Free Assays in Hit Discovery and Verification / Johannes Ottl -- Harnessing Optical Label-Free on Microtiter Plates for Lead Finding: From Binding to Phenotypes / Julio Martin -- Use of Label-Free Detection Technologies in the Hit-to-Lead Process: Surface Optical Detection of Cellular Processes / F Stuhmeier, J Bradley, E Fairman, E Gbekor, P Hayter, S Ramsey -- Cellular Screening for 7TM Receptors Using Label-Free Detection / Jeffrey C Jerman, Jason Brown, Magalie Rocheville -- Novartis Evaluation of the ForteBio Octet RED: A Versatile Instrument for Direct Binding Experiments / Eric Martin, John Wang, Isabel Zaror, Jiamin Yu, Kelly Yan, Mike Doyle, Paul Feucht, Kevin Shoemaker, Bob Warne, Mike Chin, Blisseth Sy, Lukas Leder, Marco Meyerhofer, Charles Wartchow, Danfeng Yao -- The Pyramid₉ Approach to Fragment-Based Biophysical Screening / Glyn Williams -- Characterisation of Antibodies Against the Active Conformation of G Using the SRU-BINDʼ Label-Free Detection System / Melanie Leveridge, Chun-Wa Chung, Trevor Wattam -- SPR-Based Direct Binding Assays in Drug Discovery / Walter Huber -- Kinetic Binding Mechanisms: Their Contribution to an Optimal Therapeutic Index / David C Swinney -- ITC: More Than Just Binding Affinities / Ernesto Freire -- Index.