Gene discovery for disease models /

• Άλλοι συγγραφείς: Gu, Weikuan
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : Wiley, [2011]
• Θέματα: Medical genetics.; Mutation (Biology); Genomics.; Genetic disorders.; HEALTH & FITNESS > Diseases > Genetic.; MEDICAL > Genetics.; Electronic books.

This book provides readers with new paradigms on the mutation discovery in the postgenome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes fr...

Πίνακας περιεχομένων:

• Introduction : gene discovery-from positional cloning to genomic cloning
• High throughput gene expression analysis and the identification of expression QTLs
• DNA methylation in the pathogenesis of autoimmunity
• Ccell-based analysis with microfluidic chip
• Missing dimension : protein turnover rate measurement in gene discovery
• Bioinformatics tools for the prediction of gene function
• Determination of genomic locations of targeted genetic loci
• Mutation discovery using high throughput mutation screening technology
• Candidate screening through gene expression profile
• Candidate screening through high-density SNP array
• Gene discovery through direct genome sequencing
• Candidate screening through bioinformatics tools
• Using an integrative strategy to identify mutations
• Determination of the function of a mutant in a gene
• Confirmation of a mutation by multiple molecular approaches
• Confirmation of a mutation by microRNA
• Confirmation of function of a gene by translational approaches
• Confirmation of single nucleotide mutations
• Initial identification and confirmation of a QTL gene
• Gene discovery of crop diseases in the post genome era
• Impact of whole genome genetic element analysis on gene discovery of disease models
• Impact of whole genome protein analysis on gene discovery of disease models.