Mass spectrometry in drug metabolism and disposition : basic principles and applications /
"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to...
| Άλλοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Hoboken, N.J. :
Wiley,
[2011]
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| Σειρά: | Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Frontmatter
- Basic Concepts of Drug Metabolism and Disposition. Progression of Drug Metabolism / Ronald E White
- Common Biotransformation Reactions / Bo Wen, Sidney D Nelson
- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry / Amit S Kalgutkar
- Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions / Steven W Louie, Magang Shou
- Experimental Models of Drug Metabolism and Disposition / Gang Luo, Chuang Lu, Xinxin Ding, Donglu Zhang
- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery / Takehito Yamamoto, Hiroshi Suzuki, Akihiro Hisaka
- Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes / W Griffith Humphreys
- Mass Spectrometry in Drug Metabolism: Principles and Common Practice. Theory and Instrumentation of Mass Spectrometry / Girard Hopfgartner
- Common Liquid Chromatography Mass Spectrometry (LCMS) Methodology for Metabolite Identification / Lin Xu, Lewis J Klunk, Chandra Prakash
- Mass Spectral Interpretation / Li-Kang Zhang, Birendra N Pramanik
- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection / Mark Hayward, Maria D Bacolod, Qing Ping Han, Manuel Cajina, Zack Zou
- Applications of New LCMS Techniques in Drug Metabolism and Disposition. Quantitative in Vitro ADME Assays Using LCMS as a Part of Early Drug Metabolism Screening / Walter Korfmacher
- High-Resolution Mass Spectrometry and Drug Metabolite Identification / Russell J Mortishire-Smith, Haiying Zhang, Kevin P Bateman
- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging / Richard F Reich, Daniel P Magparangalan, Timothy J Garrett, Richard A Yost
- Use of Triple Quadrupole Linear Ion Trap Mass Spectrometry as a Single LCMS Platform in Drug Metabolism and Pharmacokinetics Studies / Wenying Jian, Ming Yao, Bo Wen, Elliott B Jones, Mingshe Zhu
- Quantitative Drug Metabolism with Accelerator Mass Spectrometry / John S Vogel, Peter Lohstroh, Brad Keck, Stephen R Dueker
- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions / Jing-Tao Wu
- Profiling and Characterization of Herbal Medicine and its Metabolites Using LCMS / Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, Jian Liu
- Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices / Fumin Li, Qin C Ji
- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress / Stacy L Gelhaus, Ian A Blair
- LC²́⁶MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery / Michael D Reily, Petia Shipkova, Serhiy Hnatyshyn
- Appendix
- Index.
- (Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition
- The Progression of Drug Metabolism
- Common Biotransformation Reactions
- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry
- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions
- Experimental Models of Drug Metabolism and Disposition
- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics
- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes
- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice
- Theory and Instrumentation of Mass Spectrometry
- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification
- Mass Spectral Interpretation
- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection
- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition
- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening
- High Resolution Mass Spectrometry and Drug Metabolite Identification
- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging
- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies
- Quantitative Drug Metabolism with Accelerator Mass Spectrometry
- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions
- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS
- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices
- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress
- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.
