Kinetics of Enzyme Action : Essential Principles for Drug Hunters /

• Κύριος συγγραφέας: Stein, Ross L.
• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : Wiley, [2011]
• Θέματα: Enzymes > Pharmacokinetics.; Enzyme inhibitors > Pharmacokinetics.; Enzymes > pharmacokinetics.; Drug Discovery.; Enzyme Activation.; Enzyme Inhibitors > pharmacokinetics.; SCIENCE > Life Sciences > Biochemistry.; Electronic books.; Electronic resource.

"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions a...

Πίνακας περιεχομένων:

• Frontmatter
• Introduction
• Kinetics of Single-Substrate Enzymatic Reactions
• Kinetics of Single-Substrate Enzymatic Reactions: Special Topics
• Enzyme Inhibition: The Phenomenon and Mechanism-Independent Analysis
• Kinetic Mechanism of Inhibition of One-Substrate Enzymatic Reactions
• Tight-Binding, Slow-Binding, and Irreversible Inhibition
• Kinetics of Two-Substrate Enzymatic Reactions
• Kinetic Mechanism of Inhibition of Two-Substrate Enzymatic Reactions
• Allosteric Modulation of Enzyme Activity
• Kinetics-Based Probes of Mechanism
• Appendix A: Basic Principles of Chemical Kinetics
• Appendix B: Transition State Theory and Enzymology: Enzyme Catalytic Power and Inhibitor Design
• Appendix C: Selecting Substrate Concentrations for High-Throughput Screens
• Index.
• Kinetics of single-substrate enzymatic reactions
• Kinetics of single-substrate enzymatic reactions : special topics
• Enzyme inhibition : the phenomenon and mechanistic analysis
• Kinetic mechanism of inhibition of one-substrate enzymatic reactions
• Tight-binding, slow-binding, and irreversible inhibitors
• Kinetics of two-substrate enzymatic reactions
• Kinetic mechanism of inhibition of two-substrate enzymatic reactions
• Allosteric modulation of enzyme-catalyzed reactions
• Kinetics-based probes of enzyme mechanisms.