Protein kinases as drug targets /

• Corporate Author: Wiley InterScience (Online service)
• Other Authors: Müller, Gerhard, Klebl, Bert
• Format: eBook
• Language: English
• Published: Weinheim : Wiley-VCH ; [2011]
• Series: Methods and principles in medicinal chemistry ; 49.
• Subjects: Protein kinases > Inhibitors.; Antineoplastic agents > Development.; Protein Kinase Inhibitors > therapeutic use.; Drug Delivery Systems.; Drug Discovery.; MEDICAL > Pharmacology.; Electronic books.

With Kinase inhibitors being widely seen as the long-sought 'magic bullet' to conquer cancer, this fully comprehensive guide to kinase inhibitor drug development covers the entire drug pipeline from target identification to compound development and clinical application. Volume 1 focuses up...

Table of Contents:

• In vitro characterization of small-molecule kinase inhibitors
• Screening for kinase inhibitors: from biochemical to cellular assays
• Dissecting phosphorylation networks: the use of analogue-sensitive kinases and more specific kinase inhibitors as tools
• Rational drug design of kinase inhibitors for signal transduction therapy
• Kinaes inhibitors in signal transduction therapy
• Design principles of deep pocket-targeting protein kinase inhibitors
• From discovery to clinic: aurora kinase inhibitors as novel treatments for cancer
• Discovery and design of protein kinase inhibitors: targeting the cell cycle in oncology
• Medicinal chemistry approaches for the inhibition of the p38 MAPK pathway
• Cellular protein kinases as antiviral targets
• Prospects for TB therapeutics targeting mycobacterium tuberculosis phosphosignaling networks.