Protein chaperones and protection from neurodegenerative diseases /

• Άλλοι συγγραφείς: Witt, Stephan
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken : John Wiley & Sons, [2011]
• Σειρά: Wiley series in protein and peptide science.
• Θέματα: Molecular chaperones.; Nervous system > Degeneration.; Molecular Chaperones.; Neurodegenerative Diseases > genetics.; MEDICAL > Neuroscience.; PSYCHOLOGY > Neuropsychology.; Electronic books.; Electronic resource.

 How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population. Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic. 

 Frontmatter -- Color Plates -- Intrinsically Disordered Chaperones and Neurodegeneration / Vladimir N Uversky -- Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases / Tomohiro Nakamura, Stuart A Lipton -- Chaperone-Mediated Autophagy and Parkinson's Disease / Marta Martinez-Vicente, Ester Wong -- Chaperone and Anti-Chaperone Properties of Synuclein: Implications for Development, Aging, and Neurodegenerative Disease / Makoto Hashimoto, Kazuanri Sekiyama, Akio Sekigawa, Masayo Fujita -- The Ubiquitin₆Proteasome System in Neurodegenerative Diseases: More than the Usual Suspects / Anne Bertolotti -- Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery / Andrew P Lieberman, William B Pratt -- Amyloid Remodeling by Hsp104 / James Shorter -- Chaperone-Dependent Amyloid Assembly and Prion Toxicity / Daniel W Summers, Katie J Wolfe, Douglas M Cyr -- Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners / Daniel C Masison -- ALS and the Copper Chaperone CCS / Marjatta Son, Jeffrey L Elliott -- Emerging Area: TorsinA, a Novel ATP-Dependent Factor Linked to Dystonia / Michal Zolkiewski, Hui-Chuan Wu -- Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones / David S Gross, Ronald L Klein, Stephan N Witt -- Index.