Applications of toxicogenomics in safety evaluation and risk assessment /

• Άλλοι συγγραφείς: Boverhof, Darrell R., Gollapudi, B. Bhaskar
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2011]
• Θέματα: Genetic toxicology.; Toxicity testing.; Health risk assessment.; HEALTH & FITNESS > Diseases > Genetic.; MEDICAL > Genetics.; Toxicogenetics.; Risk Assessment.; Electronic books.; Electronic resource.

"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in info...

Πίνακας περιεχομένων:

• Toxicology, "omics" technologies, and toxicogenomics : a primer
• Introduction to human health risk assessment
• Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward
• Approaches and practical considerations for the analysis of toxicogenomics data
• Genomics in identifying mutagenic mode of action in carcinogenesis
• Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens
• Genomics in characterizing endocrine toxicity
• Studying organ specific toxicity using gene expression profiling
• Toxicogenomic studies in human populations
• Toxicogenomics applied to ecological risk assessment
• Analysis of transcriptomic dose response data for toxicology and risk assessment
• Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges
• Toxicogenomics and animal alternatives
• Toxicogenomics and the regulatory framework
• Standardization of gene expression information for the safety evaluation--activities in Japan
• Applying transcriptional profiling in drug safety evaluation
• Reframing the risk assessment paradigm : towards a systems biology approach.