Oral Bioavailability : Basic Principles, Advanced Concepts, and Applications /

• Άλλοι συγγραφείς: Hu, Ming, Ph. D., Li, Xiaoling, Ph.D
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2011]
• Σειρά: Wiley series in drug discovery and development.
• Θέματα: Drugs > Bioavailability.; Drug development.; Intestinal absorption.; Biological Availability.; Drug Delivery Systems.; Intestinal Absorption.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Electronic books.; Electronic resource.
• Φυσική περιγραφή: 1 online resource.
• Βιβλιογραφία: Includes bibliographical references.
• ISBN: 9781118067598; 1118067592; 9781118067529; 1118067525; 1283257769; 9781283257763
• DOI: 10.1002/9781118067598

Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches-Caco-2 cell culture model, MDCK, and other related cell culture models-which are used to study the science of oral bioavailability.