Systems biology in drug discovery and development /

• Other Authors: Young, Daniel L. (Editor), Michelson, Seth (Editor)
• Format: eBook
• Language: English
• Published: Hoboken, N.J. : Wiley, 2011.
• Series: Wiley series on technologies for the pharmaceutical industry.
• Subjects: Drug development.; Systems biology.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Drug Discovery > methods.; Models, Biological.; Pharmacokinetics.; Pharmacological Phenomena.; Systems Biology > methods.; Electronic books.
• Physical Description: 1 online resource.
• Bibliography: Includes bibliographical references.
• ISBN: 9780470261231; 0470261234; 9781118016435; 1118016432; 9781118016411; 1118016416
• DOI: 10.1002/9781118016435

This is the first comprehensive systems biology book to focus on its applications in drug discovery and development. Using real-world examples, the book shows how systems biology can be used to enhance pharmaceutical research and drug development. It highlights essential components of drug discovery like target identification and validation and complementary systems approaches like text-mining, large multi-context datasets and regression modeling. It also provides models for treatment personalization and methods for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker indentification. Introducing key methods and technical approaches the book addresses the challenges currently facing the drug industry.