Systems biology in drug discovery and development /

• Άλλοι συγγραφείς: Young, Daniel L. (Επιμελητής έκδοσης), Michelson, Seth (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : Wiley, 2011.
• Σειρά: Wiley series on technologies for the pharmaceutical industry.
• Θέματα: Drug development.; Systems biology.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Drug Discovery > methods.; Models, Biological.; Pharmacokinetics.; Pharmacological Phenomena.; Systems Biology > methods.; Electronic books.

This is the first comprehensive systems biology book to focus on its applications in drug discovery and development. Using real-world examples, the book shows how systems biology can be used to enhance pharmaceutical research and drug development. It highlights essential components of drug discovery...

Πίνακας περιεχομένων:

• Frontmatter
• Color Plates
• Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young
• Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle
• Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer
• Simulation of Population Variability in Pharmacokinetics / Jiansong Yang
• Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks
• Lead Identification and Optimization / Seth Michelson
• Role of Core Biological Motifs in Dose₆Response Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen
• Mechanism-Based Pharmacokinetic₆Pharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry Lav̌
• Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen
• Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar
• Simulating Clinical Trials / Tom Parke
• Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev
• Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu
• Future Outlook for Systems Biology / Daniel L Young, Seth Michelson
• Index.
• Introduction to systems biology in drug discovery and development
• Methods for in silico biology : model construction and analysis
• Methods in in silico biology : modeling feedback dynamics in pathways
• Simulation of population variability in pharmacokinetics
• Applications of systems biology approaches to target identification and validation in drug discovery
• Lead identification and optimization
• The role of core biological motifs in dose-response modeling : an example with switch-like circuits
• Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development
• Developing oncology drugs using virtual patients of vascular tumor diseases
• Systems modeling applied to candidate biomarker identification
• Simulating clinical trials
• Pathway analysis in drug discovery
• Functional mapping for predicting drug response and enabling personalized medicine
• Future outlook of systems biology.