Handbook of statistical systems biology /

• Corporate Author: Wiley InterScience (Online service)
• Other Authors: Stumpf, M. P. H. (Michael P. H.), Balding, D. J., Girolami, Mark, 1963-
• Format: eBook
• Language: English
• Published: Chichester : Wiley, 2011.
• Subjects: Systems biology > Statistical methods > Handbooks, manuals, etc.; Biological systems > Mathematical models > Handbooks, manuals, etc.; Stochastic analysis > Mathematical models > Handbooks, manuals, etc.; Electronic resource.

 Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. 

 Methodological Chapters. Two Challenges of Systems Biology / William S Hlavacek -- Introduction to Statistical Methods for Complex Systems / Tristan Mary-Huard, Sťphane Robin -- Bayesian Inference and Computation / Christian P Robert, Jean-Michel Marin, Judith Rousseau -- Data Integration: Towards Understanding Biological Complexity / David Gomez-Cabrero, Jesper Tegner -- Control Engineering Approaches to Reverse Engineering Biomolecular Networks / Francesco Montefusco, Carlo Cosentino, Declan G Bates -- Algebraic Statistics and Methods in Systems Biology / Carsten Wiuf -- Transcriptomic Technologies and Statistical Data Analysis / Elizabeth Purdom, Sach Mukherjee -- Statistical Data Analysis in Metabolomics / Timothy M D Ebbels, Maria De Iorio -- Imaging and Single-Cell Measurement Technologies / Yu-ichi Ozaki, Shinya Kuroda -- Technology-Based Chapters. Protein Interaction Networks and Their Statistical Analysis / Waqar Ali, Charlotte Deane, Gesine Reinert -- Networks and Graphical Models. Introduction to Graphical Modelling / Marco Scutari, Korbinian Strimmer -- Recovering Genetic Network from Continuous Data with Dynamic Bayesian Networks / Ga︠lle Lelandais, Sophie L̈bre -- Advanced Applications of Bayesian Networks in Systems Biology / Dirk Husmeier, Adriano V Werhli, Marco Grzegorczyk -- Random Graph Models and Their Application to Protein-Protein Interaction Networks / Desmond J Higham, Nata₍a Pr°ulj -- Modelling Biological Networks via Tailored Random Graphs / Anthony C C Coolen, Franca Fraternali, Alessia Annibale, Luis Fernandes, Jens Kleinjung -- Dynamical Systems. Nonlinear Dynamics: A Brief Introduction / Alessandro Moura, Celso Grebogi -- Qualitative Inference in Dynamical Systems / Fatihcan M Atay, Jurgen Jost -- Stochastic Dynamical Systems / Darren J Wilkinson -- Gaussian Process Inference for Differential Equation Models of Transcriptional Regulation / Neil Lawrence, Magnus Rattray, Antti Honkela, Michalis Titsias -- Model Identification by Utilizing Likelihood-Based Methods / Andreas Raue, Jens Timmer -- Application Areas. Inference of Signalling Pathway Models / Tina Toni, Juliane Liepe, Michael P H Stumpf -- Modelling Transcription Factor Activity / Martino Barenco, Daniel Brewer, Robin Callard, Michael Hubank -- Host-Pathogen Systems Biology / John W Pinney -- Bayesian Approaches for Mass Spectrometry-Based Metabolomics / Simon Rogers, Richard A Scheltema, Michael Barrett, Rainer Breitling -- Systems Biology of microRNAs / Doron Betel, Raya Khanin.