Biopharmaceutics modeling and simulations : theory, practice, methods, and applications /

BA comprehensive introduction to using modeling and simulation programs in drug discovery and development/b/ Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation des...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Sugano, Kiyohiko
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2013]
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Περιγραφή
Περίληψη:BA comprehensive introduction to using modeling and simulation programs in drug discovery and development/b/ Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs./ A guide to the basics of modeling and simulation programs, iBiopharmaceutics Modeling and Simulations/i offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses:/ ulliThe central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS)/liliThe concept of drug concentration/liliHow to simulate key drug absorption processes/liliThe physiological and drug property data used for biopharmaceutical modeling/liliReliable practices for reporting results/li/ul With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research'including running and interpreting models, validation, and compound and formulation selection'this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.
Φυσική περιγραφή:1 online resource.
Βιβλιογραφία:Includes bibliographical references and index.
ISBN:9781118354315
1118354311
9781118354322
111835432X
9781118354308
1118354303
9781118354339
1118354338
DOI:10.1002/9781118354339