Biopharmaceutics modeling and simulations : theory, practice, methods, and applications /

• Κύριος συγγραφέας: Sugano, Kiyohiko
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2013]
• Θέματα: Biopharmaceutics > Computer simulation.; Biopharmaceutics > methods.; Computer Simulation.; Drug Compounding > methods.; Models, Theoretical.; Medical.; MEDICAL > Pharmacology.; Electronic books.

 BA comprehensive introduction to using modeling and simulation programs in drug discovery and development/b/ Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs./ A guide to the basics of modeling and simulation programs, iBiopharmaceutics Modeling and Simulations/i offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses:/ ulliThe central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS)/liliThe concept of drug concentration/liliHow to simulate key drug absorption processes/liliThe physiological and drug property data used for biopharmaceutical modeling/liliReliable practices for reporting results/li/ul With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research'including running and interpreting models, validation, and compound and formulation selection'this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow. 

 Introduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice.