Biopharmaceutics modeling and simulations : theory, practice, methods, and applications /

• Κύριος συγγραφέας: Sugano, Kiyohiko
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2013]
• Θέματα: Biopharmaceutics > Computer simulation.; Biopharmaceutics > methods.; Computer Simulation.; Drug Compounding > methods.; Models, Theoretical.; Medical.; MEDICAL > Pharmacology.; Electronic books.

BA comprehensive introduction to using modeling and simulation programs in drug discovery and development/b/ Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation des...

Πίνακας περιεχομένων:

• Introduction
• Theoretical framework I : solubility
• Theoretical framework II : dissolution
• Theoretical framework III : biological membrane permeation
• Theoretical framework IV : gastrointestinal transit models and integration
• Physiology of gastrointestinal tract and other administration sites in humans and animals
• Drug parameters
• Validation of mechanistic models
• Bioequivalence and biopharmaceutical classification system
• Dose and particle size dependency
• Enabling formulations
• Food effect
• Biopharmaceutical modeling for miscellaneous cases
• Intestinal transporters
• Strategy in drug discovery and development
• Epistemology of biopharmaceutical modeling and good simulation practice.