Zebrafish : Methods for Assessing Drug Safety and Toxicity /

• Άλλοι συγγραφείς: McGrath, Patricia, 1949- (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2012]
• Θέματα: Logperch > Genetics.; Drugs > Safety measures.; Toxicology > Animal models.; Fish as laboratory animals.; Animal models in research.; NATURE > Animals > Fish.; SCIENCE > Life Sciences > Zoology > Ichthyology & Herpetology.; Electronic books.

 Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging s. 

 Frontmatter -- Color Plates -- The Reproductive Biology and Spawning of Zebrafish in Laboratory Settings / Christian Lawrence -- Developmental Toxicity Assessment in Zebrafish / Maryann Haldi, Maegan Harden, Louis D'Amico, Anthony DeLise, Wen Lin Seng -- Use of Emerging Models for Developmental Toxicity Testing / Patricia McGrath -- Assessment of Drug-Induced Cardiotoxicity in Zebrafish / Louis D'amico, Wen Lin Seng, Yi Yang, Willi Suter -- Cardiotoxicity Studies in Zebrafish / David J Milan, Calum A MacRae -- Recording of the Adult Zebrafish Electrocardiogram / David J Milan, Calum A MacRae -- Hematopoietic and Vascular System Toxicity / Alison M Taylor, Leonard I Zon -- Hepatotoxicity Testing in Larval Zebrafish / Adrian Hill -- Whole Zebrafish Cytochrome P450 Assay for Assessing Drug Metabolism and Safety / Chunqi Li, Liqing Luo, Jessica Awerman, Patricia McGrath -- Methods for Assessing Neurotoxicity in Zebrafish / Chunqi Li, Wen Lin Seng, Demian Park, Patricia McGrath -- Zebrafish: A Predictive Model for Assessing Cancer Drug-Induced Organ Toxicity / Louis D'amico, Chunqi Li, Elizabeth Glaze, Myrtle Davis, Wen Lin Seng -- Locomotion and Behavioral Toxicity in Larval Zebrafish: Background, Methods, and Data / Robert C MacPhail, Deborah L Hunter, Terra D Irons, Stephanie Padilla -- Zebrafish: A Predictive Model for Assessing Seizure Liability / Demian Park, Joshua Meidenbauer, Breanne Sparta, Wen Lin Seng, Patricia McGrath -- Zebrafish: A New Model for Identifying P-Glycoprotein Efflux Modulators / Demian Park, Maryann Haldi, Wen Lin Seng -- Assessment of Effects on Visual Function in Larval Zebrafish / Wendy Alderton -- Development of a Hypoxia-Induced Zebrafish Choroidal Neovascularization Model / Wen Lin Seng, Yingxin Lin, Susie Tang, Lisa Zhong -- Zebrafish Xenotransplant Cancer Model for Drug Screening / Chunqi Li, Liqing Luo, Patricia McGrath -- Zebrafish Assays for Identifying Potential Muscular Dystrophy Drug Candidates / Jian Tang, Susie Tang, Maryann Haldi, Wen Lin Seng -- Cytoprotective Activities of Water-Soluble Fullerenes in Zebrafish Models / Florian Beuerle, Patrick Witte, Uwe Hartnagel, Russell Lebovitz, Chuenlei Parng, Andreas Hirsch -- Fishing to Design Inherently Safer Nanoparticles / Lisa Truong, Michael T Simonich, Katerine S Saili, Robert L Tanguay -- Radiation-Induced Toxicity and Radiation Response Modifiers in Zebrafish / Adam P Dicker, Gabor Kari, Ulrich Rodeck -- Caudal Fin Regeneration in Zebrafish / Tamara Tal, Sumitra Sengupta, Robert L Tanguay -- Index.